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Int. J. Mol. Sci. 2019, 20(2), 388; https://doi.org/10.3390/ijms20020388

Modulation of the Endocannabinoid System Following Central Nervous System Injury

1
Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada
2
Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS B3H 4R2, Canada
3
Department of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada
4
Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4R2, Canada
5
Department of Physiology and Biophysics, Dalhousie University, Halifax, NS B3H 4R2, Canada
*
Author to whom correspondence should be addressed.
Received: 21 December 2018 / Accepted: 8 January 2019 / Published: 17 January 2019
(This article belongs to the Special Issue Neuroprotective Strategies 2018)
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Abstract

Central nervous system (CNS) injury, such as stroke or trauma, is known to increase susceptibility to various infections that adversely affect patient outcomes (CNS injury-induced immunodepression—CIDS). The endocannabinoid system (ECS) has been shown to have immunoregulatory properties. Therefore, the ECS might represent a druggable target to overcome CIDS. Evidence suggests that cannabinoid type 2 receptor (CB2R) activation can be protective during the early pro-inflammatory phase after CNS injury, as it limits neuro-inflammation and, therefore, attenuates CIDS severity. In the later phase post CNS injury, CB2R inhibition is suggested as a promising pharmacologic strategy to restore immune function in order to prevent infection. View Full-Text
Keywords: central nervous system injury; endocannabinoid system; immunodepression central nervous system injury; endocannabinoid system; immunodepression
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Zhou, J.; Noori, H.; Burkovskiy, I.; Lafreniere, J.D.; Kelly, M.E.M.; Lehmann, C. Modulation of the Endocannabinoid System Following Central Nervous System Injury. Int. J. Mol. Sci. 2019, 20, 388.

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