Hepatocyte Growth Factor: A Microenvironmental Resource for Leukemic Cell Growth
Abstract
:1. Introduction
2. HGF and c-MET Expression and Function in Hematological Neoplasms
3. Microenvironment as a Source of HGF in CLL
3.1. HGF Increases Viability of Leukemic Cells
3.2. CLL-Patient Monocytes Show Higher c-MET and IDO Expression than Controls Monocytes. HGF May Contribute to Drive Monocytes Toward an Immunosuppressive Phenotype
4. Therapeutic Options to Counteract HGF- and c-MET-Related Cancer Effects
5. Concluding Remarks
Author Contributions
Funding
Conflict of Interest
References
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Neoplasia of Mature B Cells | Neoplastic Cells | c-MET Activation | Refs | |||
---|---|---|---|---|---|---|
c-MET | HGF | HGFA | Autocrine | Paracrine | ||
Mantle Cell Lymphoma | − | − | n.d. | − | − | [34] |
Marginal Zone Lymphoma | − | − | n.d. | − | − | [34] |
Follicular Lymphoma | +/− | − | n.d. | − | + | [34] |
Diffuse Large B Cell Lymphoma | + | − | + | − | + | [34,35] |
Chronic Lymphocytic Leukemia | +/− | +/− | +/− | + | + | [21,34,56] |
Burkitt Lymphoma | +/− | − | n.d. | − | + | [30,33,34] |
Primary Effusion Lymphoma | + | + | + | + | + | [30] |
Multiple Myeloma | + | + | + | + | + | [47,48,50] |
Hodgkin Lymphoma | + | − | n.d. | − | + | [51,52,53] |
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Giannoni, P.; Fais, F.; Cutrona, G.; Totero, D.d. Hepatocyte Growth Factor: A Microenvironmental Resource for Leukemic Cell Growth. Int. J. Mol. Sci. 2019, 20, 292. https://doi.org/10.3390/ijms20020292
Giannoni P, Fais F, Cutrona G, Totero Dd. Hepatocyte Growth Factor: A Microenvironmental Resource for Leukemic Cell Growth. International Journal of Molecular Sciences. 2019; 20(2):292. https://doi.org/10.3390/ijms20020292
Chicago/Turabian StyleGiannoni, Paolo, Franco Fais, Giovanna Cutrona, and Daniela de Totero. 2019. "Hepatocyte Growth Factor: A Microenvironmental Resource for Leukemic Cell Growth" International Journal of Molecular Sciences 20, no. 2: 292. https://doi.org/10.3390/ijms20020292