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Int. J. Mol. Sci. 2019, 20(2), 277; https://doi.org/10.3390/ijms20020277

Platelet-Rich Plasma in Treatment of Temporomandibular Joint Dysfunctions: Narrative Review

1
Department of Surgery, Dentistry, Paediatric and Gynaecology, University of Verona. Policlinico G. B. Rossi. Piazzale L. Scuro n.10, 37134 Verona, Italy
2
Section of Anatomy and Pathophysiology, Department of Clinical and Experimental Sciences, University of Brescia, 25100 Brescia, Italy
*
Author to whom correspondence should be addressed.
Received: 14 December 2018 / Revised: 7 January 2019 / Accepted: 9 January 2019 / Published: 11 January 2019
(This article belongs to the Special Issue Head Tissues Regeneration)
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Abstract

Background: The aims of this narrative review were to examine up-to-date literature in order to evaluate the effectiveness of arthrocentesis or injections with platelet-rich plasma in temporomandibular affections and to compare them to arthrocentesis alone or with hyaluronic acid (HA) or to hyaluronic acid injections. Methods: The search of international literature was made on the PMC, PubMed and Cochrane databases, including all full-length text of studies on humans focused on osteoarthritis and disc displacements and their treatment with platelet-rich plasma arthrocentesis or injections. All design studies were included in the review and they were examined for three different outcomes: pain, joint sound and mandibular motion. English papers were only selected. Results: Even though the low number of studies in this field, arthrocentesis with platelet-rich plasma and platelet-rich plasma injections in temporomandibular disorders’ management were found to be effective in reducing pain and joint sound as well as in improving mandibular motion in a maximum follow-up of 24 months. Conclusion: Comparison to arthrocentesis alone or to HA use in arthrocentesis or by injections provided encouraging results in terms of the effectiveness of platelet-rich plasma use. View Full-Text
Keywords: temporomandibular joint (TMJ); temporomandibular joint disorders (TMD); platelet-rich plasma; arthrocentesis; injection; hyaluronic acid temporomandibular joint (TMJ); temporomandibular joint disorders (TMD); platelet-rich plasma; arthrocentesis; injection; hyaluronic acid
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Zotti, F.; Albanese, M.; Rodella, L.F.; Nocini, P.F. Platelet-Rich Plasma in Treatment of Temporomandibular Joint Dysfunctions: Narrative Review. Int. J. Mol. Sci. 2019, 20, 277.

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