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Int. J. Mol. Sci. 2019, 20(2), 278; https://doi.org/10.3390/ijms20020278

Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms

1,2,†
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1,2,†
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1,2,†
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3
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3
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1,2
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4
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1,2,*
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5,*
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1,2,3,*
and
3,6,7
1
Department of Oral Implantology, School of Dentistry, Jilin University, Changchun 130021, China
2
Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering, Changchun 130021, China
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Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA
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State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China
5
Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Department of Prosthodontics, School of Stomatology, Shandong University, Jinan 250012, China
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Center for Stem Cell Biology and Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
7
University of Maryland Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
*
Authors to whom correspondence should be addressed.
These authors contribute equally to this work.
Received: 19 December 2018 / Revised: 9 January 2019 / Accepted: 9 January 2019 / Published: 11 January 2019
(This article belongs to the Special Issue Polymeric Systems as Antimicrobial or Antifouling Agents)
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Abstract

Periodontitis is a common infectious disease characterized by loss of tooth-supporting structures, which eventually leads to tooth loss. The heavy burden of periodontal disease and its negative consequence on the patient’s quality of life indicate a strong need for developing effective therapies. According to the World Health Organization, 10–15% of the global population suffers from severe periodontitis. Advances in understanding the etiology, epidemiology and microbiology of periodontal pocket flora have called for antibacterial therapeutic strategies for periodontitis treatment. Currently, antimicrobial strategies combining with polymer science have attracted tremendous interest in the last decade. This review focuses on the state of the art of antibacterial polymer application against periodontal pathogens and biofilms. The first part focuses on the different polymeric materials serving as antibacterial agents, drug carriers and periodontal barrier membranes to inhibit periodontal pathogens. The second part reviews cutting-edge research on the synthesis and evaluation of a new generation of bioactive dental polymers for Class-V restorations with therapeutic effects. They possess antibacterial, acid-reduction, protein-repellent, and remineralization capabilities. In addition, the antibacterial photodynamic therapy with polymeric materials against periodontal pathogens and biofilms is also briefly described in the third part. These novel bioactive and therapeutic polymeric materials and treatment methods have great potential to inhibit periodontitis and protect tooth structures. View Full-Text
Keywords: polymers; antibacterial; drug delivery; periodontitis; periodontal biofilms polymers; antibacterial; drug delivery; periodontitis; periodontal biofilms
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Chi, M.; Qi, M.; A, L.; Wang, P.; Weir, M.D.; Melo, M.A.; Sun, X.; Dong, B.; Li, C.; Wu, J.; Wang, L.; Xu, H.H.K. Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms. Int. J. Mol. Sci. 2019, 20, 278.

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