Next Article in Journal
Answer to Controversy: miR-10a Replacement Approaches Do Not Offer Protection against Chemotherapy-Induced Gonadotoxicity in Mouse Model
Next Article in Special Issue
Lysozyme-Induced Transcriptional Regulation of TNF-α Pathway Genes in Cells of the Monocyte Lineage
Previous Article in Journal
OsATG8c-Mediated Increased Autophagy Regulates the Yield and Nitrogen Use Efficiency in Rice
Previous Article in Special Issue
Effects of Extract of Arrabidaea chica Verlot on an Experimental Model of Osteoarthritis
Open AccessReview

Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders

1
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran
2
Department of Biochemistry, University of Allahabad, Allahabad 211 002, India
3
Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA
4
Bioorganic Chemistry Laboratory, Facultad de Ciencias Básicas y Aplicadas, Campus Nueva Granada, Universidad Militar Nueva Granada, Cajicá 250247, Colombia
5
Research Institute of Biotechnology and Medical Converged Science, Dongguk University-Seoul, Ilsandong-gu, Gyeonggi-do 10326, Korea
6
Post Graduate Department of Biotechnology, Utkal University, Vani Vihar, Bhubaneswar 751 004, Odisha, India
7
Department of Pharmacy, University of Naples “Federico II”, Via Domenico Montesano 49, 80131 Naples, Italy
8
Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan
9
Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy
10
Medicinal Plants Research Center, Institute of Medicinal Plants, Karaj 141554364, Iran
11
Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences, Tehran University of Medical Sciences, Tehran 141556451, Iran
12
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(19), 4957; https://doi.org/10.3390/ijms20194957
Received: 29 August 2019 / Revised: 28 September 2019 / Accepted: 30 September 2019 / Published: 8 October 2019
(This article belongs to the Special Issue Natural Anti-Inflammatory Agents 2019)
A balanced metabolic profile is essential for normal human physiological activities. Disproportions in nutrition give rise to imbalances in metabolism that are associated with aberrant immune function and an elevated risk for inflammatory-associated disorders. Inflammation is a complex process, and numerous mediators affect inflammation-mediated disorders. The available clinical modalities do not effectively address the underlying diseases but rather relieve the symptoms. Therefore, novel targeted agents have the potential to normalize the metabolic system and, thus, provide meaningful therapy to the underlying disorder. In this connection, polyphenols, the well-known and extensively studied phytochemical moieties, were evaluated for their effective role in the restoration of metabolism via various mechanistic signaling pathways. The various flavonoids that we observed in this comprehensive review interfere with the metabolic events that induce inflammation. The mechanisms via which the polyphenols, in particular flavonoids, act provide a promising treatment option for inflammatory disorders. However, detailed clinical studies of such molecules are required to decide their clinical fate. View Full-Text
Keywords: flavonoids; metabolic disorders; inflammation; oxidative stress; nuclear factor-κB; inflammatory mediators flavonoids; metabolic disorders; inflammation; oxidative stress; nuclear factor-κB; inflammatory mediators
Show Figures

Figure 1

MDPI and ACS Style

Farzaei, M.H.; Singh, A.K.; Kumar, R.; Croley, C.R.; Pandey, A.K.; Coy-Barrera, E.; Kumar Patra, J.; Das, G.; Kerry, R.G.; Annunziata, G.; Tenore, G.C.; Khan, H.; Micucci, M.; Budriesi, R.; Momtaz, S.; Nabavi, S.M.; Bishayee, A. Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders. Int. J. Mol. Sci. 2019, 20, 4957.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop