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Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders

Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran
Department of Biochemistry, University of Allahabad, Allahabad 211 002, India
Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA
Bioorganic Chemistry Laboratory, Facultad de Ciencias Básicas y Aplicadas, Campus Nueva Granada, Universidad Militar Nueva Granada, Cajicá 250247, Colombia
Research Institute of Biotechnology and Medical Converged Science, Dongguk University-Seoul, Ilsandong-gu, Gyeonggi-do 10326, Korea
Post Graduate Department of Biotechnology, Utkal University, Vani Vihar, Bhubaneswar 751 004, Odisha, India
Department of Pharmacy, University of Naples “Federico II”, Via Domenico Montesano 49, 80131 Naples, Italy
Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan
Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy
Medicinal Plants Research Center, Institute of Medicinal Plants, Karaj 141554364, Iran
Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences, Tehran University of Medical Sciences, Tehran 141556451, Iran
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(19), 4957;
Received: 29 August 2019 / Revised: 28 September 2019 / Accepted: 30 September 2019 / Published: 8 October 2019
(This article belongs to the Special Issue Natural Anti-Inflammatory Agents 2019)
A balanced metabolic profile is essential for normal human physiological activities. Disproportions in nutrition give rise to imbalances in metabolism that are associated with aberrant immune function and an elevated risk for inflammatory-associated disorders. Inflammation is a complex process, and numerous mediators affect inflammation-mediated disorders. The available clinical modalities do not effectively address the underlying diseases but rather relieve the symptoms. Therefore, novel targeted agents have the potential to normalize the metabolic system and, thus, provide meaningful therapy to the underlying disorder. In this connection, polyphenols, the well-known and extensively studied phytochemical moieties, were evaluated for their effective role in the restoration of metabolism via various mechanistic signaling pathways. The various flavonoids that we observed in this comprehensive review interfere with the metabolic events that induce inflammation. The mechanisms via which the polyphenols, in particular flavonoids, act provide a promising treatment option for inflammatory disorders. However, detailed clinical studies of such molecules are required to decide their clinical fate. View Full-Text
Keywords: flavonoids; metabolic disorders; inflammation; oxidative stress; nuclear factor-κB; inflammatory mediators flavonoids; metabolic disorders; inflammation; oxidative stress; nuclear factor-κB; inflammatory mediators
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Farzaei, M.H.; Singh, A.K.; Kumar, R.; Croley, C.R.; Pandey, A.K.; Coy-Barrera, E.; Kumar Patra, J.; Das, G.; Kerry, R.G.; Annunziata, G.; Tenore, G.C.; Khan, H.; Micucci, M.; Budriesi, R.; Momtaz, S.; Nabavi, S.M.; Bishayee, A. Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders. Int. J. Mol. Sci. 2019, 20, 4957.

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