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Selecting an Appropriate Animal Model of Depression

Joint Program of Nanchang University and Queen Mary University of London, Nanchang 330006, China
Department of Physiology, The Basic Medical College of Nanchang University, Nanchang 330006, China
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(19), 4827;
Received: 15 September 2019 / Accepted: 26 September 2019 / Published: 28 September 2019
(This article belongs to the Special Issue Animal Models of Parkinson's Disease and Related Disorders)
Depression has become one of the most severe psychiatric disorders and endangers the health of living beings all over the world. In order to explore the molecular mechanism that underlies depression, different kinds of animal models of depression are used in laboratory experiments. However, a credible and reasonable animal model that is capable of imitating the pathologic mechanism of depression in mankind has yet to be found, resulting in a barrier to further investigation of depression. Nevertheless, it is possible to explain the pathologic mechanism of depression to a great extent by a rational modeling method and behavioral testing. This review aims to provide a reference for researchers by comparing the advantages and disadvantages of some common animal depression models. View Full-Text
Keywords: depression; animal model; behavior test depression; animal model; behavior test
MDPI and ACS Style

Hao, Y.; Ge, H.; Sun, M.; Gao, Y. Selecting an Appropriate Animal Model of Depression. Int. J. Mol. Sci. 2019, 20, 4827.

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