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Article

Chinese Herbal Medicine Ganoderma tsugae Displays Potential Anti-Cancer Efficacy on Metastatic Prostate Cancer Cells

1
Graduate Institute of Biomedical Sciences, School of Medicine, China Medical University, Taichung 40402, Taiwan
2
Department of Biological Science and Technology, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung 40402, Taiwan
3
Department of Chinese Medicine, China Medical University Hospital, Taichung 40402, Taiwan
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Research Center for Traditional Chinese Medicine, Department of Medical Research, China Medical University, Taichung 40402, Taiwan
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Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan
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Research Center for Chinese Herbal Medicine, China Medical University, Taichung 40402, Taiwan
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Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(18), 4418; https://doi.org/10.3390/ijms20184418
Received: 29 July 2019 / Revised: 6 September 2019 / Accepted: 6 September 2019 / Published: 8 September 2019
(This article belongs to the Special Issue Multikinase Inhibitors and Cancer)
Resistance to the current therapies is the main clinical challenge in the treatment of lethal metastatic prostate cancer (mPCa). Developing novel therapeutic approaches with effective regimes and minimal side effects for this fatal disease remain a priority in prostate cancer study. In the present study, we demonstrated that a traditional Chinese medicine, quality-assured Ganoderma tsugae ethanol extract (GTEE), significantly suppressed cell growth and metastatic capability and caused cell cycle arrest through decreasing expression of cyclins in mPCa cells, PC-3 and DU145 cells. GTEE also induced caspase-dependent apoptosis in mPCa cells. We further showed the potent therapeutic efficacy of GTEE by inhibiting subcutaneous PC-3 tumor growth in a xenograft model. The in vitro and in vivo efficacies on mPCa cells were due to blockade of the PI3K/Akt and MAPK/ERK signaling pathways associated with cancer cell growth, survival and apoptosis. These preclinical data provide the molecular basis for a new potential therapeutic approach toward the treatment of lethal prostate cancer progression. View Full-Text
Keywords: anti-cancer efficacy; prostate cancer; metastasis; Ganoderma tsugae; Chinese herbal medicine anti-cancer efficacy; prostate cancer; metastasis; Ganoderma tsugae; Chinese herbal medicine
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MDPI and ACS Style

Huang, W.-C.; Chang, M.-S.; Huang, S.-Y.; Tsai, C.-J.; Kuo, P.-H.; Chang, H.-W.; Huang, S.-T.; Kuo, C.-L.; Lee, S.-L.; Kao, M.-C. Chinese Herbal Medicine Ganoderma tsugae Displays Potential Anti-Cancer Efficacy on Metastatic Prostate Cancer Cells. Int. J. Mol. Sci. 2019, 20, 4418. https://doi.org/10.3390/ijms20184418

AMA Style

Huang W-C, Chang M-S, Huang S-Y, Tsai C-J, Kuo P-H, Chang H-W, Huang S-T, Kuo C-L, Lee S-L, Kao M-C. Chinese Herbal Medicine Ganoderma tsugae Displays Potential Anti-Cancer Efficacy on Metastatic Prostate Cancer Cells. International Journal of Molecular Sciences. 2019; 20(18):4418. https://doi.org/10.3390/ijms20184418

Chicago/Turabian Style

Huang, Wen-Chin, Meng-Shiun Chang, Shih-Yin Huang, Ching-Ju Tsai, Pin-Hung Kuo, Han-Wen Chang, Sheng-Teng Huang, Chao-Lin Kuo, Shou-Lun Lee, and Ming-Ching Kao. 2019. "Chinese Herbal Medicine Ganoderma tsugae Displays Potential Anti-Cancer Efficacy on Metastatic Prostate Cancer Cells" International Journal of Molecular Sciences 20, no. 18: 4418. https://doi.org/10.3390/ijms20184418

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