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Open AccessReview

Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis

1
Medical and Biological Sciences Building, School of Biology, University of St Andrews, St Andrews KY16 9TF, UK
2
Biomedical Science Research Centre, Schools of Chemistry and Biology, University of St Andrews, St Andrews KY16 9TF, UK
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(12), 3108; https://doi.org/10.3390/ijms20123108
Received: 27 May 2019 / Revised: 15 June 2019 / Accepted: 16 June 2019 / Published: 25 June 2019
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PDF [11848 KB, uploaded 26 June 2019]
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Abstract

Drug delivery to the central nervous system (CNS) conferred by brain barriers is a major obstacle in the development of effective neurotherapeutics. In this review, a classification of current approaches of clinical or investigational importance for the delivery of therapeutics to the CNS is presented. This classification includes the use of formulations administered systemically that can elicit transcytosis-mediated transport by interacting with transporters expressed by transvascular endothelial cells. Neurotherapeutics can also be delivered to the CNS by means of surgical intervention using specialized catheters or implantable reservoirs. Strategies for delivering drugs to the CNS have evolved tremendously during the last two decades, yet, some factors can affect the quality of data generated in preclinical investigation, which can hamper the extension of the applications of these strategies into clinically useful tools. Here, we disclose some of these factors and propose some solutions that may prove valuable at bridging the gap between preclinical findings and clinical trials. View Full-Text
Keywords: CNS-targeted drug delivery; Blood-brain barrier; Receptor-mediated transcytosis; Transient BBB disruption; Efflux-pump inhibition; Ring-opening metathesis polymerization CNS-targeted drug delivery; Blood-brain barrier; Receptor-mediated transcytosis; Transient BBB disruption; Efflux-pump inhibition; Ring-opening metathesis polymerization
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Abdul Razzak, R.; Florence, G.J.; Gunn-Moore, F.J. Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis. Int. J. Mol. Sci. 2019, 20, 3108.

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