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Review

LncRNAs Regulatory Networks in Cellular Senescence

Department of Molecular and Functional Genomics, Weis Center for Research, Geisinger Clinic, Danville, PA 17822, USA
Int. J. Mol. Sci. 2019, 20(11), 2615; https://doi.org/10.3390/ijms20112615
Received: 21 March 2019 / Revised: 19 April 2019 / Accepted: 6 May 2019 / Published: 28 May 2019
(This article belongs to the Collection Regulation by Non-Coding RNAs)
Long noncoding RNAs (lncRNAs) are a class of transcripts longer than 200 nucleotides with no open reading frame. They play a key role in the regulation of cellular processes such as genome integrity, chromatin organization, gene expression, translation regulation, and signal transduction. Recent studies indicated that lncRNAs are not only dysregulated in different types of diseases but also function as direct effectors or mediators for many pathological symptoms. This review focuses on the current findings of the lncRNAs and their dysregulated signaling pathways in senescence. Different functional mechanisms of lncRNAs and their downstream signaling pathways are integrated to provide a bird’s-eye view of lncRNA networks in senescence. This review not only highlights the role of lncRNAs in cell fate decision but also discusses how several feedback loops are interconnected to execute persistent senescence response. Finally, the significance of lncRNAs in senescence-associated diseases and their therapeutic and diagnostic potentials are highlighted. View Full-Text
Keywords: senescence; lncRNAs; signaling pathways; cancer; aging senescence; lncRNAs; signaling pathways; cancer; aging
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MDPI and ACS Style

Puvvula, P.K. LncRNAs Regulatory Networks in Cellular Senescence. Int. J. Mol. Sci. 2019, 20, 2615. https://doi.org/10.3390/ijms20112615

AMA Style

Puvvula PK. LncRNAs Regulatory Networks in Cellular Senescence. International Journal of Molecular Sciences. 2019; 20(11):2615. https://doi.org/10.3390/ijms20112615

Chicago/Turabian Style

Puvvula, Pavan K. 2019. "LncRNAs Regulatory Networks in Cellular Senescence" Int. J. Mol. Sci. 20, no. 11: 2615. https://doi.org/10.3390/ijms20112615

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