Next Article in Journal
Topical Application of TGF-β-Activating Peptide, KRFK, Prevents Inflammatory Manifestations in the TSP-1-Deficient Mouse Model of Chronic Ocular Inflammation
Next Article in Special Issue
LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks
Previous Article in Journal
Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model
Previous Article in Special Issue
Oxidative Stress as Cause, Consequence, or Biomarker of Altered Female Reproduction and Development in the Space Environment

Proteomic Analysis of Mouse Brain Subjected to Spaceflight

Department of Basic Sciences, Division of Biomedical Engineering Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
Department of Pathology and Human Anatomy, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
Department of Medical Biochemistry and Biophysics, Biomedicum, Karolinska Institutet, SE 17177 Stockholm, Sweden
Department of Pharmacological and Technological Chemistry, I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia
BioServe Space Technologies, University of Colorado at Boulder, Boulder, CO 80303, USA
Department of Bioengineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(1), 7;
Received: 9 November 2018 / Revised: 11 December 2018 / Accepted: 17 December 2018 / Published: 20 December 2018
There is evidence that spaceflight poses acute and late risks to the central nervous system. To explore possible mechanisms, the proteomic changes following spaceflight in mouse brain were characterized. Space Shuttle Atlantis (STS-135) was launched from the Kennedy Space Center (KSC) on a 13-day mission. Within 3–5 h after landing, brain tissue was collected to evaluate protein expression profiles using quantitative proteomic analysis. Our results showed that there were 26 proteins that were significantly altered after spaceflight in the gray and/or white matter. While there was no overlap between the white and gray matter in terms of individual proteins, there was overlap in terms of function, synaptic plasticity, vesical activity, protein/organelle transport, and metabolism. Our data demonstrate that exposure to the spaceflight environment induces significant changes in protein expression related to neuronal structure and metabolic function. This might lead to a significant impact on brain structural and functional integrity that could affect the outcome of space missions. View Full-Text
Keywords: brain; spaceflight; microgravity; proteomics brain; spaceflight; microgravity; proteomics
MDPI and ACS Style

Mao, X.W.; Sandberg, L.B.; Gridley, D.S.; Herrmann, E.C.; Zhang, G.; Raghavan, R.; Zubarev, R.A.; Zhang, B.; Stodieck, L.S.; Ferguson, V.L.; Bateman, T.A.; Pecaut, M.J. Proteomic Analysis of Mouse Brain Subjected to Spaceflight. Int. J. Mol. Sci. 2019, 20, 7.

AMA Style

Mao XW, Sandberg LB, Gridley DS, Herrmann EC, Zhang G, Raghavan R, Zubarev RA, Zhang B, Stodieck LS, Ferguson VL, Bateman TA, Pecaut MJ. Proteomic Analysis of Mouse Brain Subjected to Spaceflight. International Journal of Molecular Sciences. 2019; 20(1):7.

Chicago/Turabian Style

Mao, Xiao W., Lawrence B. Sandberg, Daila S. Gridley, E. C. Herrmann, Guangyu Zhang, Ravi Raghavan, Roman A. Zubarev, Bo Zhang, Louis S. Stodieck, Virginia L. Ferguson, Ted A. Bateman, and Michael J. Pecaut 2019. "Proteomic Analysis of Mouse Brain Subjected to Spaceflight" International Journal of Molecular Sciences 20, no. 1: 7.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop