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Nutrition and Cardiovascular Health
Open AccessArticle

Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model

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Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia
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Department of Human Pathology, 1st Moscow State Medical, University IM Sechenov, Trubetskaya street 8, Moscow 119991, Russia
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Department of Pharmacy, High Medical School of Professional Studies in Cuprija, Lole Ribara 1/2, 35000 Cuprija, Serbia
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Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia
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Institute of Histology and Embryology “Aleksandar Dj. Kostic”, Faculty of Medicine, University of Belgrade, Dr Subotic 8, 11000 Belgrad, Serbia
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Pharmanova, Generala Anrija 6, 11010 Belgrade, Serbia
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Institute for Medical Research, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Tadeusa Koscuska 1, 11129 Belgrade, Serbia
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(1), 6; https://doi.org/10.3390/ijms20010006
Received: 30 November 2018 / Revised: 11 December 2018 / Accepted: 12 December 2018 / Published: 20 December 2018
(This article belongs to the Special Issue Nutrition and Cardiovascular Health)
The aim of our study was to examine the effects of different dietary strategies, high-fat (HFd) or standard diet (Sd) alone or in combination with standardized oral supplementation (0.45 mL/kg/day) of Aronia melanocarpa extract (SAE) in rats with metabolic syndrome (MetS). SAE is an official product of pharmaceutical company Pharmanova (Belgrade, Serbia); however, the procedure for extraction was done by EU-Chem company (Belgrade, Serbia). Rats were divided randomly into six groups: control with Sd, control with Sd and SAE, MetS with HFd, MetS with HFd and SAE, MetS with Sd and MetS with Sd and SAE during 4 weeks. At the end of the 4-week protocol, cardiac function and liver morphology were assessed, while in the blood samples glucose, insulin, iron levels and systemic redox state were determined. Our results demonstrated that SAE had the ability to lower blood pressure and exert benefits on in vivo and ex vivo heart function. Moreover, SAE improved glucose tolerance, attenuated pathological liver alterations and oxidative stress present in MetS. Obtained beneficial effects of SAE were more prominent in combination with changing dietary habits. Promising potential of SAE supplementation alone or in combination with different dietary protocols in triggering cardioprotection should be further examined in future. View Full-Text
Keywords: metabolic syndrome; Aronia melanocarpa; standardized extract; dietary strategies; supplementation metabolic syndrome; Aronia melanocarpa; standardized extract; dietary strategies; supplementation
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JAKOVLJEVIC, V.; Milic, P.; Bradic, J.; Jeremic, J.; Zivkovic, V.; Srejovic, I.; Nikolic Turnic, T.; Milosavljevic, I.; Jeremic, N.; Bolevich, S.; Labudovic Borovic, M.; Mitrovic, M.; Vucic, V. Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model. Int. J. Mol. Sci. 2019, 20, 6.

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