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Int. J. Mol. Sci. 2018, 19(12), 3729; https://doi.org/10.3390/ijms19123729

Oxidative Stress as Cause, Consequence, or Biomarker of Altered Female Reproduction and Development in the Space Environment

1
Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Colorado School of Medicine, Aurora, CO 80249, USA
2
Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA
3
Space BioSciences Division, NASA Ames Research Center, Moffett Field, CA 94305, USA
4
Department of Obstetrics & Gynecology, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA
*
Author to whom correspondence should be addressed.
Received: 10 October 2018 / Revised: 12 November 2018 / Accepted: 20 November 2018 / Published: 23 November 2018
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Abstract

Oxidative stress has been implicated in the pathophysiology of numerous terrestrial disease processes and associated with morbidity following spaceflight. Furthermore, oxidative stress has long been considered a causative agent in adverse reproductive outcomes. The purpose of this review is to summarize the pathogenesis of oxidative stress caused by cosmic radiation and microgravity, review the relationship between oxidative stress and reproductive outcomes in females, and explore what role spaceflight-induced oxidative damage may have on female reproductive and developmental outcomes. View Full-Text
Keywords: oxidative stress; cosmic radiation; microgravity; hind-limb unloading; spaceflight; reproduction; female; pregnancy oxidative stress; cosmic radiation; microgravity; hind-limb unloading; spaceflight; reproduction; female; pregnancy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Steller, J.G.; Alberts, J.R.; Ronca, A.E. Oxidative Stress as Cause, Consequence, or Biomarker of Altered Female Reproduction and Development in the Space Environment. Int. J. Mol. Sci. 2018, 19, 3729.

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