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Etiology of Metabolic Syndrome and Dietary Intervention

Department of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, TX 77843, USA
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(1), 128;
Received: 21 November 2018 / Revised: 20 December 2018 / Accepted: 25 December 2018 / Published: 31 December 2018
(This article belongs to the Special Issue Kinase Signal Transduction 2019)
The growing prevalence of metabolic syndrome (MetS) in the U.S. and even worldwide is becoming a serious health problem and economic burden. MetS has become a crucial risk factor for the development of type 2 diabetes mellitus (T2D) and cardiovascular diseases (CVD). The rising rates of CVD and diabetes, which are the two leading causes of death, simultaneously exist. To prevent the progression of MetS to diabetes and CVD, we have to understand how MetS occurs and how it progresses. Too many causative factors interact with each other, making the investigation and treatment of metabolic syndrome a very complex issue. Recently, a number of studies were conducted to investigate mechanisms and interventions of MetS, from different aspects. In this review, the proposed and demonstrated mechanisms of MetS pathogenesis are discussed and summarized. More importantly, different interventions are discussed, so that health practitioners can have a better understanding of the most recent research progress and have available references for their daily practice. View Full-Text
Keywords: metabolic syndrome; obesity; insulin resistance; personal nutrition; dietary intervention metabolic syndrome; obesity; insulin resistance; personal nutrition; dietary intervention
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Xu, H.; Li, X.; Adams, H.; Kubena, K.; Guo, S. Etiology of Metabolic Syndrome and Dietary Intervention. Int. J. Mol. Sci. 2019, 20, 128.

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