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Int. J. Mol. Sci. 2019, 20(1), 127; https://doi.org/10.3390/ijms20010127

Exercise Training Impacts Cardiac Mitochondrial Proteome Remodeling in Murine Urothelial Carcinoma

1
QOPNA-Química Orgânica, Produtos Naturais e Agroalimentares, Departamento de Química, Universidade de Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal
2
CIAFEL-Centro de Investigação em Actividade Física, Saúde e Lazer, Faculdade de Desporto, Universidade do Porto, R. Dr. Plácido da Costa 91, 4200-450 Porto, Portugal
3
iBiMED-Institute of Biomedicine, Departamento de Ciências Médicas, Universidade de Aveiro, Agra do Crasto, 3810-193 Aveiro, Portugal
4
Departamento de Cirurgia e Fisiologia, Faculdade de Medicina, Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal
5
i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4020-135 Porto, Portugal
6
INEB-Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-180 Porto, Portugal
7
Grupo de Patologia e Terapêutica Experimental, Instituto Português de Oncologia, R. Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal
8
CITAB-Centre for the Research and Technology of Agro-Environmental and Biological Sciences, Departamento de Ciências Veterinárias, Universidade de Trás-os-Montes e Alto Douro, Quinta de Prados, 5001-911 Vila Real, Portugal
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 27 November 2018 / Revised: 21 December 2018 / Accepted: 24 December 2018 / Published: 31 December 2018
(This article belongs to the Special Issue Molecular Research Efforts in Urothelial Carcinoma)
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Abstract

Cardiac dysfunction secondary to cancer may exert a negative impact in patients’ tolerance to therapeutics, quality of life, and survival. The aim of this study was to evaluate the potential therapeutic effect of exercise training on the heart in the setting of cancer, after diagnosis. Thus, the molecular pathways harbored in heart mitochondria from a murine model of chemically-induced urothelial carcinoma submitted to 8-weeks of high intensity treadmill exercise were characterized using mass spectrometry-based proteomics. Data highlight the protective effects of high intensity exercise training in preventing left ventricle diastolic dysfunction, fibrosis, and structural derangement observed in tumor-bearing mice. At the mitochondrial level, exercise training counteracted the lower ability to produce ATP observed in the heart of animals with urothelial carcinoma and induced the up-regulation of fatty acid oxidation and down-regulation of the biological process “cardiac morphogenesis”. Taken together, our data support the prescription of exercise training after cancer diagnosis for the management of disease-related cardiac dysfunction. View Full-Text
Keywords: cardiac remodeling; treadmill running; HPLC–MS/MS; cardiac morphogenesis; metabolism cardiac remodeling; treadmill running; HPLC–MS/MS; cardiac morphogenesis; metabolism
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ferreira, R.; Neuparth, M.J.; Nogueira-Ferreira, R.; Magalhães, S.; Aroso, M.; Bovolini, J.A.; Lara Santos, L.; Oliveira, P.; Vitorino, R.; Moreira-Gonçalves, D. Exercise Training Impacts Cardiac Mitochondrial Proteome Remodeling in Murine Urothelial Carcinoma. Int. J. Mol. Sci. 2019, 20, 127.

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