Next Article in Journal
LAIPT: Lysine Acetylation Site Identification with Polynomial Tree
Next Article in Special Issue
Steam Reforming of Model Bio-Oil Aqueous Fraction Using Ni-(Cu, Co, Cr)/SBA-15 Catalysts
Previous Article in Journal
A Novel Approach Based on a Weighted Interactive Network to Predict Associations of MiRNAs and Diseases
Previous Article in Special Issue
Construction of a Glutathione-Responsive and Silica-Based Nanocomposite for Controlled Release of Chelator Dimercaptosuccinic Acid
Open AccessArticle

Electrochemical Detection of Dopamine at a Gold Electrode Modified with a Polypyrrole–Mesoporous Silica Molecular Sieves (MCM-48) Film

Institute of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245 Bialystok, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(1), 111; https://doi.org/10.3390/ijms20010111
Received: 23 November 2018 / Revised: 13 December 2018 / Accepted: 20 December 2018 / Published: 29 December 2018
(This article belongs to the Special Issue Mesoporous Materials: From Synthesis to Applications)
A gold electrode modified with a polypyrrole–mesoporous silica molecular sieves (polypyrrole—MCM-48) nanostructure film was used for the electrochemical determination of small concentrations of dopamine (DA) by cyclic voltammetry and square-wave voltammetry techniques. This electrode showed good electrocatalytic activity for the oxidation of dopamine. The oxidation potential of dopamine was decreased significantly compared with that obtained at the bare gold electrode. The observed linear range for the determination of the dopamine concentration, without interferents through cyclic voltammetry measurements, was from 10 μM to 1.2 mM (R2 = 0.9989) for the gold electrode modified with the polypyrrole—MCM-48 nanostructure, with a detection limit of 2.5 μM. In the case of square-wave voltammetry, the linear range was 2–250 μM, with a correlation coefficient of 0.9996, and the detection limit was estimated to be 0.7 μM. The effects of interferents, such as ascorbic acid (AA) and uric acid (UA), on the electrochemical detection of dopamine were also examined. The modified electrode can successfully separate the oxidation potentials for ascorbic acid and dopamine, shifting the oxidation peak potential of ascorbic acid to a more positive potential, and significantly decreasing the peak current. The presence of ascorbic acid increased the sensitivity of dopamine determination at the modified electrode, and the detection limit was estimated to be 0.5 μM with 0.1 mM ascorbic acid to imitate physiological solutions. Additionally, studies showed that the presence of uric acid does not affect the electrochemical detection of dopamine. The modified electrode can be successfully applied for the quantitative analysis of dopamine both with and without interferents. View Full-Text
Keywords: mesoporous silica; polypyrrole; MCM-48; polypyrrole composite; dopamine mesoporous silica; polypyrrole; MCM-48; polypyrrole composite; dopamine
Show Figures

Figure 1

MDPI and ACS Style

Zablocka, I.; Wysocka-Zolopa, M.; Winkler, K. Electrochemical Detection of Dopamine at a Gold Electrode Modified with a Polypyrrole–Mesoporous Silica Molecular Sieves (MCM-48) Film. Int. J. Mol. Sci. 2019, 20, 111.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop