A Novel Approach Based on a Weighted Interactive Network to Predict Associations of MiRNAs and Diseases
Abstract
:1. Introduction
2. Results and Case Studies
2.1. Comparison with Existing State-of-the-Art Methods
2.2. Evaluation of the Effects of Parameters
2.2.1. Effects of Parameter T
2.2.2. Effects of Parameter w
2.3. Case Studies
3. Discussion
4. Materials and Methods
4.1. Construction of the miRNA–Disease Interactive Network
4.2. Calculation of the Disease Semantic Similarity
4.3. Calculation of the miRNA Functional Similarity
4.4. Disease Gaussian Interaction Profile Kernel Similarity Measurement
4.5. MicroRNA Gaussian Interaction Profile Kernel Similarity Measurement
4.6. Calculation of the Integrated Similarity
4.7. Construction of the Weighted Interactive Network
4.8. Calculation of the Shortest Path Based on the Weighted Interactive Network
4.9. Calculation of the Shortest Path Based on the Weighted Interactive Network
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
miRNAs | MicroRNAs |
WINMDA | Weighted interactive network for discovering potential miRNA–disease associations |
CXCL8 | C–X–C ligand 8 |
ROC | receiver operating characteristics |
AUC | Area of ROC under the curve |
LOOCV | Leave-one-out cross-validation |
OC | Ovarian cancer |
ncRNAs | Non-coding RNAs |
MeSH | Medical Subject Headings |
DAGs | Direct acyclic graphs |
HMDD | Human microRNA Disease Database |
LncRNA | long non-coding RNA |
NEAT 1 | nuclear paraspeckle assembly transcript 1 |
SNPs | single-nucleotide polymorphisms |
dbDEMC | Differentially Expressed miRNAs in Human Cancers |
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LOOCV | 5-Fold Cross-Validation | 10-Fold Cross-Validation |
---|---|---|
0.9243 | 0.9183 ± 0.0007 | 0.9200 ± 0.0004 |
T | AUC | T | AUC |
---|---|---|---|
1 | 0.9145 | 12 | 0.9241 |
2 | 0.9160 | 16 | 0.9243 |
5 | 0.9222 | 18 | 0.9242 |
8 | 0.9244 | 20 | 0.9188 |
w | AUC | w | AUC |
---|---|---|---|
0 | 0.9135 | 0.6 | 0.9243 |
0.1 | 0.9188 | 0.7 | 0.9239 |
0.2 | 0.9209 | 0.8 | 0.9222 |
0.3 0.4 0.5 | 0.9216 0.9235 0.9241 | 0.9 1 | 0.9189 0.9160 |
Top 1–25 miRNAs | Evidence | Top 26–50 miRNAs | Evidence |
---|---|---|---|
hsa-mir-143 | dbDEMC and miR2Disease | hsa-let-7e | dbDEMC |
hsa-mir-20a | dbDEMC and miR2Disease | hsa-mir-486 | 26895105 |
hsa-mir-34a | dbDEMC and miR2Disease | hsa-mir-133b | dbDEMC and miR2Disease |
hsa-mir-210 | dbDEMC | hsa-mir-200a | unconfirmed |
hsa-mir-21 | dbDEMC and miR2Disease | hsa-mir-141 | dbDEMC and miR2Disease |
hsa-mir-155 | dbDEMC and miR2Disease | hsa-let-7f | dbDEMC and miR2Disease |
hsa-mir-95 | dbDEMC and miR2Disease | hsa-mir-29a | dbDEMC and miR2Disease |
hsa-mir-146a | dbDEMC | hsa-mir-181a | dbDEMC and miR2Disease |
hsa-mir-16 | dbDEMC | hsa-mir-9 | dbDEMC and miR2Disease |
hsa-mir-125b | dbDEMC | hsa-mir-29b | dbDEMC and miR2Disease |
hsa-mir-92a | unconfirmed | hsa-let-7c | dbDEMC |
hsa-mir-31 | dbDEMC and miR2Disease | hsa-let-7d | dbDEMC |
hsa-mir-223 | dbDEMC and miR2Disease | hsa-mir-196a | dbDEMC and miR2Disease |
hsa-mir-221 | dbDEMC and miR2Disease | hsa-let-7i | dbDEMC |
hsa-mir-222 | dbDEMC | hsa-mir-142 | 23619912 |
hsa-let-7a | dbDEMC and miR2Disease | hsa-mir-1 | dbDEMC and miR2Disease |
hsa-mir-19b | dbDEMC and miR2Disease | hsa-mir-133a | dbDEMC and miR2Disease |
hsa-mir-15a | dbDEMC | hsa-mir-192 | dbDEMC and miR2Disease |
hsa-mir-18a | dbDEMC and miR2Disease | hsa-mir-150 | 26455323 |
hsa-mir-200b | dbDEMC | hsa-mir-203 | dbDEMC and miR2Disease |
hsa-mir-19a | dbDEMC and miR2Disease | hsa-mir-451a | 25484364 |
hsa-let-7b | dbDEMC and miR2Disease | hsa-let-7g | dbDEMC and miR2Disease |
hsa-mir-24 | miR2Disease | hsa-mir-124 | dbDEMC |
hsa-mir-199a | unconfirmed | hsa-mir-224 | dbDEMC and miR2Disease |
hsa-mir-200c | dbDEMC and miR2Disease | hsa-mir-146b | 28466779 |
Top 1–25 miRNAs | Evidence | Top 26–50 miRNAs | Evidence |
---|---|---|---|
hsa-mir-146b | 26673617 | hsa-mir-20a | 29450946 |
hsa-mir-130a | 25834316 | hsa-mir-375 | 21343377 |
hsa-mir-21 | miR2Disease | hsa-mir-17 | 30024601 |
hsa-mir-146a | 28922434 | hsa-mir-222 | miR2Disease |
hsa-mir-155 | 26950485 | hsa-mir-101 | 28944848 |
hsa-mir-145 | miR2Disease | hsa-mir-199a | 24655788 |
hsa-mir-143 | miR2Disease | hsa-mir-22 | 28482669 |
hsa-mir-200a | 25740983 | hsa-mir-196a | 24527072 |
hsa-mir-200b | 25740983 | hsa-mir-223 | 22270966 |
hsa-mir-126 | 26464628 | hsa-mir-7 | 26261179 |
hsa-mir-200c | 27766962 | hsa-mir-34c | 18803879 |
hsa-let-7a | miR2Disease | hsa-mir-122 | 29509059 |
hsa-mir-141 | miR2Disease | hsa-mir-218 | 27696291 |
hsa-mir-34a | 25834316 | hsa-mir-34b | unconfirmed |
hsa-mir-142 | 21343377 | hsa-mir-10b | 25190020 |
hsa-mir-31 | 19598010 | hsa-mir-103a | 29754469 |
hsa-mir-16 | miR2Disease | hsa-mir-27a | miR2Disease |
hsa-mir-192 | 24981590 | hsa-mir-150 | 20067763 |
hsa-mir-486 | 26895105 | hsa-mir-18a | 26950485 |
hsa-mir-221 | miR2Disease | hsa-mir-19a | 22802949 |
hsa-mir-107 | miR2Disease | hsa-mir-106a | miR2Disease |
hsa-let-7f | 21533124 | hsa-mir-9 | 28418879 |
hsa-let-7g | 25972194 | hsa-mir-451a | unconfirmed |
hsa-mir-133b | 23296701 | hsa-mir-124 | 27041578 |
hsa-mir-125b | 24846940 | hsa-mir-1 | 25874496 |
Top 1–25 miRNAs | Evidence | Top 26–50 miRNAs | Evidence |
---|---|---|---|
hsa-mir-143 | dbDEMC and miR2Disease | hsa-mir-15a | dbDEMC and miR2Disease |
hsa-mir-182 | dbDEMC and miR2Disease | hsa-mir-181b | dbDEMC and miR2Disease |
hsa-mir-96 | dbDEMC and miR2Disease | hsa-mir-375 | dbDEMC and miR2Disease |
hsa-mir-34a | dbDEMC and miR2Disease | hsa-mir-200a | dbDEMC |
hsa-mir-210 | miR2Disease | hsa-mir-34b | dbDEMC |
hsa-mir-150 | dbDEMC | hsa-mir-34c | dbDEMC |
hsa-mir-92a | Unconfirmed | hsa-let-7b | dbDEMC and miR2Disease |
hsa-mir-141 | miR2Disease | hsa-mir-218 | dbDEMC and miR2Disease |
hsa-mir-21 | dbDEMC and miR2Disease | hsa-mir-101 | dbDEMC and miR2Disease |
hsa-mir-222 | dbDEMC and miR2Disease | hsa-mir-124 | dbDEMC |
hsa-mir-31 | dbDEMC and miR2Disease | hsa-mir-223 | dbDEMC and miR2Disease |
hsa-mir-146b | 25712341 | hsa-let-7a | dbDEMC and miR2Disease |
hsa-mir-221 | dbDEMC and miR2Disease | hsa-mir-224 | dbDEMC and miR2Disease |
hsa-mir-203 | 26499781 | hsa-mir-205 | dbDEMC and miR2Disease |
hsa-mir-126 | dbDEMC and miR2Disease | hsa-let-7d | dbDEMC and miR2Disease |
hsa-mir-200b | Unconfirmed | hsa-mir-1 | dbDEMC |
hsa-mir-200c | dbDEMC | hsa-let-7c | dbDEMC and miR2Disease |
hsa-mir-146a | miR2Disease | hsa-mir-127 | dbDEMC and miR2Disease |
hsa-mir-17 | miR2Disease | hsa-mir-135b | dbDEMC |
hsa-mir-100 | dbDEMC and miR2Disease | hsa-mir-214 | dbDEMC and miR2Disease |
hsa-mir-16 | dbDEMC and miR2Disease | hsa-mir-93 | 26124181 |
hsa-mir-199a | dbDEMC and miR2Disease | hsa-mir-708 | 22552290 |
hsa-mir-20a | miR2Disease | hsa-mir-155 | dbDEMC |
hsa-mir-133b | dbDEMC | hsa-mir-133a | dbDEMC |
hsa-mir-27b | dbDEMC and miR2Disease | hsa-mir-195 | dbDEMC and miR2Disease |
Disease | WINMDA | BNPMDA | PBMDA | WBSMDA | RLSMDA |
---|---|---|---|---|---|
Breast neoplasms | 44 | 48 | 46 | 36 | 42 |
Colon neoplasms | 47 | 45 | 47 | 45 | 46 |
Gastric neoplasms | 48 | 43 | 46 | 43 | 44 |
Kidney neoplasms | 45 | 43 | 42 | 42 | 45 |
Liver neoplasms | 48 | 45 | 45 | 46 | 46 |
Prostate neoplasms | 48 | 44 | 45 | 42 | 44 |
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Zhao, H.; Kuang, L.; Feng, X.; Zou, Q.; Wang, L. A Novel Approach Based on a Weighted Interactive Network to Predict Associations of MiRNAs and Diseases. Int. J. Mol. Sci. 2019, 20, 110. https://doi.org/10.3390/ijms20010110
Zhao H, Kuang L, Feng X, Zou Q, Wang L. A Novel Approach Based on a Weighted Interactive Network to Predict Associations of MiRNAs and Diseases. International Journal of Molecular Sciences. 2019; 20(1):110. https://doi.org/10.3390/ijms20010110
Chicago/Turabian StyleZhao, Haochen, Linai Kuang, Xiang Feng, Quan Zou, and Lei Wang. 2019. "A Novel Approach Based on a Weighted Interactive Network to Predict Associations of MiRNAs and Diseases" International Journal of Molecular Sciences 20, no. 1: 110. https://doi.org/10.3390/ijms20010110