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Volume 19
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10.3390/ijms19092795
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Review

Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy

by
Sungmin Lee
1,
Beomseok Son
1,
Gaeul Park
1,
Hyunwoo Kim
1,
Hyunkoo Kang
1,
Jaewan Jeon
1,
HyeSook Youn
2,* and
BuHyun Youn
1,3,*
1
Department of Integrated Biological Science, Pusan National University, Busan 46241, Korea
2
Department of Integrative Bioscience and Biotechnology, Sejong University, Seoul 05006, Korea
3
Department of Biological Sciences, Pusan National University, Busan 46241, Korea
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(9), 2795; https://doi.org/10.3390/ijms19092795
Submission received: 24 August 2018 / Revised: 11 September 2018 / Accepted: 13 September 2018 / Published: 17 September 2018
(This article belongs to the Special Issue Partnership of Radiotherapy and Immunotherapy)
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Abstract

Hyperthermia is a cancer treatment where tumor tissue is heated to around 40 °C. Hyperthermia shows both cancer cell cytotoxicity and immune response stimulation via immune cell activation. Immunogenic responses encompass the innate and adaptive immune systems, involving the activation of macrophages, natural killer cells, dendritic cells, and T cells. Moreover, hyperthermia is commonly used in combination with different treatment modalities, such as radiotherapy and chemotherapy, for better clinical outcomes. In this review, we will focus on hyperthermia-induced immunogenic effects and molecular events to improve radiotherapy efficacy. The beneficial potential of integrating radiotherapy with hyperthermia is also discussed.
Keywords: hyperthermia; immunotherapy; radiotherapy; combination therapy hyperthermia; immunotherapy; radiotherapy; combination therapy

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MDPI and ACS Style

Lee, S.; Son, B.; Park, G.; Kim, H.; Kang, H.; Jeon, J.; Youn, H.; Youn, B. Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy. Int. J. Mol. Sci. 2018, 19, 2795. https://doi.org/10.3390/ijms19092795

AMA Style

Lee S, Son B, Park G, Kim H, Kang H, Jeon J, Youn H, Youn B. Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy. International Journal of Molecular Sciences. 2018; 19(9):2795. https://doi.org/10.3390/ijms19092795

Chicago/Turabian Style

Lee, Sungmin, Beomseok Son, Gaeul Park, Hyunwoo Kim, Hyunkoo Kang, Jaewan Jeon, HyeSook Youn, and BuHyun Youn. 2018. "Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy" International Journal of Molecular Sciences 19, no. 9: 2795. https://doi.org/10.3390/ijms19092795

APA Style

Lee, S., Son, B., Park, G., Kim, H., Kang, H., Jeon, J., Youn, H., & Youn, B. (2018). Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy. International Journal of Molecular Sciences, 19(9), 2795. https://doi.org/10.3390/ijms19092795

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