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Int. J. Mol. Sci. 2018, 19(9), 2775; https://doi.org/10.3390/ijms19092775

Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification

1
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland
2
Lipidomics Consulting Ltd., Irisviksvägen 31D, 02230 Esbo, Finland
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 29 August 2018 / Revised: 11 September 2018 / Accepted: 12 September 2018 / Published: 15 September 2018
(This article belongs to the Collection Advances in Proteomic Research)
Full-Text   |   PDF [5153 KB, uploaded 15 September 2018]   |  

Abstract

Inflammatory bowel disease (IBD) represents a group of progressive disorders characterized by recurrent chronic inflammation of the gut. Ulcerative colitis and Crohn′s disease are the major manifestations of IBD. While our understanding of IBD has progressed in recent years, its etiology is far from being fully understood, resulting in suboptimal treatment options. Complementing other biological endpoints, bioanalytical “omics” methods that quantify many biomolecules simultaneously have great potential in the dissection of the complex pathogenesis of IBD. In this review, we focus on the rapidly evolving proteomics and lipidomics technologies and their broad applicability to IBD studies; these range from investigations of immune-regulatory mechanisms and biomarker discovery to studies dissecting host–microbiome interactions and the role of intestinal epithelial cells. Future studies can leverage recent advances, including improved analytical methodologies, additional relevant sample types, and integrative multi-omics analyses. Proteomics and lipidomics could effectively accelerate the development of novel targeted treatments and the discovery of complementary biomarkers, enabling continuous monitoring of the treatment response of individual patients; this may allow further refinement of treatment and, ultimately, facilitate a personalized medicine approach to IBD. View Full-Text
Keywords: inflammatory bowel disease; proteomics; lipidomics; biomarkers; personalized medicine inflammatory bowel disease; proteomics; lipidomics; biomarkers; personalized medicine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Titz, B.; Gadaleta, R.M.; Lo Sasso, G.; Elamin, A.; Ekroos, K.; Ivanov, N.V.; Peitsch, M.C.; Hoeng, J. Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification. Int. J. Mol. Sci. 2018, 19, 2775.

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