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Int. J. Mol. Sci. 2018, 19(9), 2774; https://doi.org/10.3390/ijms19092774

Spatholobus suberectus Ameliorates Diabetes-Induced Renal Damage by Suppressing Advanced Glycation End Products in db/db Mice

1
Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju_Gun, Jeollabuk-do 55365, Korea
2
Divison of Food Biotechnology, University of Science and Technology, Daejeon 305350, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 16 August 2018 / Revised: 12 September 2018 / Accepted: 12 September 2018 / Published: 14 September 2018
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Spatholobus suberectus (SS) is a medicinal herb commonly used in Asia to treat anemia, menoxenia and rheumatism. However, its effect of diabetes-induced renal damage and mechanisms of action against advanced glycation end-products (AGEs) are unclear. In this study, we evaluated the effects of SS on diabetes-induced renal damage and explored the possible underlying mechanisms using db/db type 2 diabetes mice. db/db mice were administered SS extract (50 mg/kg) orally for 6 weeks. SS-treated group did not change body weight, blood glucose and glycated hemoglobin (HbA1c) levels. However, SS treatment reversed diabetes-induced dyslipidemia and urinary albumin/creatinine ratio in db/db mice. Moreover, SS administration showed significantly increased protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), which is a transcription factor for antioxidant enzyme. SS significantly upregulated glyoxalase 1 (Glo1) and NADPH quinine oxidoreductase 1 (NQO1) expression but reduced CML accumulation and downregulated receptor for AGEs (RAGE). Furthermore, SS showed significant decrease of periodic acid–Schiff (PAS)-positive staining and AGEs accumulation in histological and immunohistochemical analyses of kidney tissues. Taken together, we concluded that SS ameliorated the renal damage by inhibiting diabetes-induced glucotoxicity, dyslipidemia and oxidative stress, through the Nrf2/antioxidant responsive element (ARE) stress-response system. View Full-Text
Keywords: advanced glycation end products (AGEs); diabetic nephropathy; nuclear factor erythroid 2-related factor 2 (Nrf2); glyoxalase 1 (Glo1); Spatholobus suberectus advanced glycation end products (AGEs); diabetic nephropathy; nuclear factor erythroid 2-related factor 2 (Nrf2); glyoxalase 1 (Glo1); Spatholobus suberectus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Do, M.H.; Hur, J.; Choi, J.; Kim, Y.; Park, H.-Y.; Ha, S.K. Spatholobus suberectus Ameliorates Diabetes-Induced Renal Damage by Suppressing Advanced Glycation End Products in db/db Mice. Int. J. Mol. Sci. 2018, 19, 2774.

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