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Int. J. Mol. Sci. 2018, 19(9), 2724; https://doi.org/10.3390/ijms19092724

The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas

1
Professor Emeritus of Neurology, University of Turin, Corso Bramante 88/90, 10126 Turin, Italy
2
Department of Health Sciences, School of Medicine, University of Eastern Piedmont, 28100 Novara, Italy
3
Former Research Centre/Policlinico di Monza Foundation, Via P. Micca 29, 13100 Vercelli, Italy
4
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, 10126 Turin, Italy
5
Department of Medical Sciences, University of Turin/Città della Salute e della Scienza, Via Santena 7, 10126 Turin, Italy
*
Author to whom correspondence should be addressed.
Received: 24 July 2018 / Revised: 27 August 2018 / Accepted: 28 August 2018 / Published: 12 September 2018
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Abstract

Neuron glial antigen 2 (NG2) is a chondroitin sulphate proteoglycan 4 (CSPG4) that occurs in developing and adult central nervous systems (CNSs) as a marker of oligodendrocyte precursor cells (OPCs) together with platelet-derived growth factor receptor α (PDGFRα). It behaves variably in different pathological conditions, and is possibly involved in the origin and progression of human gliomas. In the latter, NG2/CSPG4 induces cell proliferation and migration, is highly expressed in pericytes, and plays a role in neoangiogenesis. NG2/CSPG4 expression has been demonstrated in oligodendrogliomas, astrocytomas, and glioblastomas (GB), and it correlates with malignancy. In rat tumors transplacentally induced by N-ethyl-N-nitrosourea (ENU), NG2/CSPG4 expression correlates with PDGFRα, Olig2, Sox10, and Nkx2.2, and with new vessel formation. In this review, we attempt to summarize the normal and pathogenic functions of NG2/CSPG4, as well as its potential as a therapeutic target. View Full-Text
Keywords: NG2/CSPG4; CNS; vessels; gliomagenesis; development NG2/CSPG4; CNS; vessels; gliomagenesis; development
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Schiffer, D.; Mellai, M.; Boldorini, R.; Bisogno, I.; Grifoni, S.; Corona, C.; Bertero, L.; Cassoni, P.; Casalone, C.; Annovazzi, L. The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas. Int. J. Mol. Sci. 2018, 19, 2724.

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