The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas
AbstractNeuron glial antigen 2 (NG2) is a chondroitin sulphate proteoglycan 4 (CSPG4) that occurs in developing and adult central nervous systems (CNSs) as a marker of oligodendrocyte precursor cells (OPCs) together with platelet-derived growth factor receptor α (PDGFRα). It behaves variably in different pathological conditions, and is possibly involved in the origin and progression of human gliomas. In the latter, NG2/CSPG4 induces cell proliferation and migration, is highly expressed in pericytes, and plays a role in neoangiogenesis. NG2/CSPG4 expression has been demonstrated in oligodendrogliomas, astrocytomas, and glioblastomas (GB), and it correlates with malignancy. In rat tumors transplacentally induced by N-ethyl-N-nitrosourea (ENU), NG2/CSPG4 expression correlates with PDGFRα, Olig2, Sox10, and Nkx2.2, and with new vessel formation. In this review, we attempt to summarize the normal and pathogenic functions of NG2/CSPG4, as well as its potential as a therapeutic target. View Full-Text
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Schiffer, D.; Mellai, M.; Boldorini, R.; Bisogno, I.; Grifoni, S.; Corona, C.; Bertero, L.; Cassoni, P.; Casalone, C.; Annovazzi, L. The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas. Int. J. Mol. Sci. 2018, 19, 2724.
Schiffer D, Mellai M, Boldorini R, Bisogno I, Grifoni S, Corona C, Bertero L, Cassoni P, Casalone C, Annovazzi L. The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas. International Journal of Molecular Sciences. 2018; 19(9):2724.Chicago/Turabian Style
Schiffer, Davide; Mellai, Marta; Boldorini, Renzo; Bisogno, Ilaria; Grifoni, Silvia; Corona, Cristiano; Bertero, Luca; Cassoni, Paola; Casalone, Cristina; Annovazzi, Laura. 2018. "The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas." Int. J. Mol. Sci. 19, no. 9: 2724.
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