Next Article in Journal
K+ and Rb+ Affinities of the Na,K-ATPase α1 and α2 Isozymes: An Application of ICP-MS for Quantification of Na+ Pump Kinetics in Myofibers
Next Article in Special Issue
Drug Repurposing of Metabolic Agents in Malignant Glioma
Previous Article in Journal
Chaperone-E3 Ligase Complex HSP70-CHIP Mediates Ubiquitination of Ribosomal Protein S3
Previous Article in Special Issue
Exosomal Chaperones and miRNAs in Gliomagenesis: State-of-Art and Theranostics Perspectives
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(9), 2724;

The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas

Professor Emeritus of Neurology, University of Turin, Corso Bramante 88/90, 10126 Turin, Italy
Department of Health Sciences, School of Medicine, University of Eastern Piedmont, 28100 Novara, Italy
Former Research Centre/Policlinico di Monza Foundation, Via P. Micca 29, 13100 Vercelli, Italy
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, 10126 Turin, Italy
Department of Medical Sciences, University of Turin/Città della Salute e della Scienza, Via Santena 7, 10126 Turin, Italy
Author to whom correspondence should be addressed.
Received: 24 July 2018 / Revised: 27 August 2018 / Accepted: 28 August 2018 / Published: 12 September 2018
Full-Text   |   PDF [2671 KB, uploaded 13 September 2018]   |  


Neuron glial antigen 2 (NG2) is a chondroitin sulphate proteoglycan 4 (CSPG4) that occurs in developing and adult central nervous systems (CNSs) as a marker of oligodendrocyte precursor cells (OPCs) together with platelet-derived growth factor receptor α (PDGFRα). It behaves variably in different pathological conditions, and is possibly involved in the origin and progression of human gliomas. In the latter, NG2/CSPG4 induces cell proliferation and migration, is highly expressed in pericytes, and plays a role in neoangiogenesis. NG2/CSPG4 expression has been demonstrated in oligodendrogliomas, astrocytomas, and glioblastomas (GB), and it correlates with malignancy. In rat tumors transplacentally induced by N-ethyl-N-nitrosourea (ENU), NG2/CSPG4 expression correlates with PDGFRα, Olig2, Sox10, and Nkx2.2, and with new vessel formation. In this review, we attempt to summarize the normal and pathogenic functions of NG2/CSPG4, as well as its potential as a therapeutic target. View Full-Text
Keywords: NG2/CSPG4; CNS; vessels; gliomagenesis; development NG2/CSPG4; CNS; vessels; gliomagenesis; development

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Schiffer, D.; Mellai, M.; Boldorini, R.; Bisogno, I.; Grifoni, S.; Corona, C.; Bertero, L.; Cassoni, P.; Casalone, C.; Annovazzi, L. The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas. Int. J. Mol. Sci. 2018, 19, 2724.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top