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Int. J. Mol. Sci. 2018, 19(9), 2768; https://doi.org/10.3390/ijms19092768

Drug Repurposing of Metabolic Agents in Malignant Glioma

Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, 93053 Regensburg, Germany
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Received: 15 August 2018 / Revised: 10 September 2018 / Accepted: 11 September 2018 / Published: 14 September 2018
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Abstract

Gliomas are highly invasive brain tumors with short patient survival. One major pathogenic factor is aberrant tumor metabolism, which may be targeted with different specific and unspecific agents. Drug repurposing is of increasing interest in glioma research. Drugs interfering with the patient’s metabolism may also influence glioma metabolism. In this review, we outline definitions and methods for drug repurposing. Furthermore, we give insights into important candidates for a metabolic drug repurposing, namely metformin, statins, non-steroidal anti-inflammatory drugs, disulfiram and lonidamine. Advantages and pitfalls of drug repurposing will finally be discussed. View Full-Text
Keywords: glioma; glioblastoma; drug repurposing; metformin; statin; NSAR; disulfiram; lonidamine glioma; glioblastoma; drug repurposing; metformin; statin; NSAR; disulfiram; lonidamine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Seliger, C.; Hau, P. Drug Repurposing of Metabolic Agents in Malignant Glioma. Int. J. Mol. Sci. 2018, 19, 2768.

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