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Int. J. Mol. Sci. 2018, 19(9), 2688; https://doi.org/10.3390/ijms19092688

MiRNA Dysregulation in Childhood Hematological Cancer

1
Department Genetics, Federal University of Paraná, 80060-000 Paraná, Brazil
2
Department of Pediatrics, Ribeirão Preto School of Medicine, University of São Paulo, 14049-900 Ribeirão Preto, Brazil
3
Programa de Pós-graduação em Farmácia, Anhanguera University of São Paulo, UNIAN/SP, 05145-200 São Paulo, Brazil
4
Departamento de Biologia, Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, 14040-901 Ribeirão Preto, Brazil
*
Author to whom correspondence should be addressed.
Received: 20 July 2018 / Revised: 3 September 2018 / Accepted: 8 September 2018 / Published: 10 September 2018
(This article belongs to the Special Issue MicroRNA as Biomarkers in Cancer Diagnostics and Therapy)
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Abstract

For decades, cancer biology focused largely on the protein-encoding genes that have clear roles in tumor development or progression: cell-cycle control, apoptotic evasion, genome instability, drug resistance, or signaling pathways that stimulate growth, angiogenesis, or metastasis. MicroRNAs (miRNAs), however, represent one of the more abundant classes of cell modulators in multicellular organisms and largely contribute to regulating gene expression. Many of the ~2500 miRNAs discovered to date in humans regulate vital biological processes, and their aberrant expression results in pathological and malignant outcomes. In this review, we highlight what has been learned about the roles of miRNAs in some of the most common human pediatric leukemias and lymphomas, along with their value as diagnostic/prognostic factors. View Full-Text
Keywords: miRNA; cancer; children; leukemia; lymphoma; review miRNA; cancer; children; leukemia; lymphoma; review
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Carvalho de Oliveira, J.; Molinari Roberto, G.; Baroni, M.; Bezerra Salomão, K.; Alejandra Pezuk, J.; Sol Brassesco, M. MiRNA Dysregulation in Childhood Hematological Cancer. Int. J. Mol. Sci. 2018, 19, 2688.

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