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Article

Clinicopathologic Significance of VHL Gene Alteration in Clear-Cell Renal Cell Carcinoma: An Updated Meta-Analysis and Review

Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Seoul 07441, Korea
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(9), 2529; https://doi.org/10.3390/ijms19092529
Received: 6 August 2018 / Revised: 18 August 2018 / Accepted: 24 August 2018 / Published: 26 August 2018
(This article belongs to the Section Biochemistry)
The von Hippel-Lindau (VHL) gene is inactivated frequently in sporadic clear-cell renal cell carcinomas (ccRCCs) by genetic alteration (mutation, loss of heterozygosity, or promoter hypermethylation). However, the pathological or prognostic significance of VHL gene alteration has not been well defined. We conducted this meta-analysis to evaluate the association between VHL alteration and clinopathologic findings in ccRCCs. We performed a systematic computerized search of online databases, including PubMed, EMBASE, Web of Science, and Google Scholar (up to July 2018). From ten studies, 1,082 patients were included in the pooled analyses of odds ratios (ORs) with 95% confidence intervals (CIs) for pathological features (nuclear grade and disease stage) or hazard ratios (HRs) with 95% CIs for overall survival (OS). VHL alteration was not significantly associated with nuclear grade (OR = 0.79, 95% CI: 0.59–1.06, p = 0.12) or disease stage (OR = 1.07, 95% CI: 0.79–1.46, p = 0.65). There was also no significant correlation between VHL alteration and OS (HR = 0.75, 95% CI: 0.43–1.29, p = 0.30). When we pooled HRs for OS according to the VHL alteration types, the combined HRs were 0.72 (95% CI: 0.47–1.11, p = 0.14) for VHL mutations and 1.32 (95% CI: 0.70–2.47, p = 0.39) for methylation. In conclusion, this meta-analysis indicates that VHL gene alteration is not significantly associated with the pathological features and survival in patients with ccRCC. View Full-Text
Keywords: renal cell carcinoma; von Hippel-Lindau; mutations; methylation; meta-analysis; review renal cell carcinoma; von Hippel-Lindau; mutations; methylation; meta-analysis; review
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MDPI and ACS Style

Kim, H.S.; Kim, J.H.; Jang, H.J.; Han, B.; Zang, D.Y. Clinicopathologic Significance of VHL Gene Alteration in Clear-Cell Renal Cell Carcinoma: An Updated Meta-Analysis and Review. Int. J. Mol. Sci. 2018, 19, 2529. https://doi.org/10.3390/ijms19092529

AMA Style

Kim HS, Kim JH, Jang HJ, Han B, Zang DY. Clinicopathologic Significance of VHL Gene Alteration in Clear-Cell Renal Cell Carcinoma: An Updated Meta-Analysis and Review. International Journal of Molecular Sciences. 2018; 19(9):2529. https://doi.org/10.3390/ijms19092529

Chicago/Turabian Style

Kim, Hyeong S., Jung H. Kim, Hyun J. Jang, Boram Han, and Dae Y. Zang 2018. "Clinicopathologic Significance of VHL Gene Alteration in Clear-Cell Renal Cell Carcinoma: An Updated Meta-Analysis and Review" International Journal of Molecular Sciences 19, no. 9: 2529. https://doi.org/10.3390/ijms19092529

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