Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress

Cacciotti, Ilaria; Ciocci, Matteo; Di Giovanni, Emilia; Nanni, Francesca; Melino, Sonia

doi:10.3390/ijms19082368

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Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress

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Department of Engineering, University of Rome “Niccolò Cusano”, via Don Carlo Gnocchi 3, 00166 Rome, Italy

Italian Interuniversity Consortium on Materials Science and Technology (INSTM), 50121 Florence, Italy

CIMER Center for Regenerative Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy

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Department of Chemical Science and Technologies, University of Rome “Tor Vergata”, via della Ricerca Scientifica1, 00133 Rome, Italy

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Enterprise Engineering Department, University of Rome “Tor Vergata”, via del Politecnico 1, 00133 Rome, Italy

Authors to whom correspondence should be addressed.

Int. J. Mol. Sci. 2018, 19(8), 2368; https://doi.org/10.3390/ijms19082368

Received: 4 July 2018 / Revised: 7 August 2018 / Accepted: 8 August 2018 / Published: 11 August 2018

(This article belongs to the Special Issue Cell Colonization in Scaffolds)

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Abstract

The design of biomaterial platforms able to release bioactive molecules is mandatory in tissue repair and regenerative medicine. In this context, electrospinning is a user-friendly, versatile and low-cost technique, able to process different kinds of materials in micro- and nano-fibers with a large surface area-to-volume ratio for an optimal release of gaseous signaling molecules. Recently, the antioxidant and anti-inflammatory properties of the endogenous gasotramsmitter hydrogen sulfide (H₂S), as well as its ability to stimulate relevant biochemical processes on the growth of mesenchymal stem cells (MSC), have been investigated. Therefore, in this work, new poly(lactic) acid fibrous membranes (PFM), doped and functionalized with H₂S slow-releasing donors extracted from garlic, were synthetized. These innovative H₂S-releasing mats were characterized for their morphological, thermal, mechanical, and biological properties. Their antimicrobial activity and effects on the in vitro human cardiac MSC growth, either in the presence or in the absence of oxidative stress, were here assessed. On the basis of the results here presented, these new H₂S-releasing PFM could represent promising and low-cost scaffolds or patches for biomedical applications in tissue repair. View Full-Text

Keywords: PLA fibers; organosulfur compounds; garlic extracts; mesenchymal stem cells; microstructure; thermal and mechanical properties; cytotoxicity; antibacterial properties

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Cacciotti, I.; Ciocci, M.; Di Giovanni, E.; Nanni, F.; Melino, S. Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress. Int. J. Mol. Sci. 2018, 19, 2368. https://doi.org/10.3390/ijms19082368

AMA Style

Cacciotti I, Ciocci M, Di Giovanni E, Nanni F, Melino S. Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress. International Journal of Molecular Sciences. 2018; 19(8):2368. https://doi.org/10.3390/ijms19082368

Chicago/Turabian Style

Cacciotti, Ilaria, Matteo Ciocci, Emilia Di Giovanni, Francesca Nanni, and Sonia Melino. 2018. "Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress" International Journal of Molecular Sciences 19, no. 8: 2368. https://doi.org/10.3390/ijms19082368

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Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress

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