RETRACTED: Sargassum serratifolium Extract Attenuates Interleukin-1β-Induced Oxidative Stress and Inflammatory Response in Chondrocytes by Suppressing the Activation of NF-κB, p38 MAPK, and PI3K/Akt

Park, Cheol; Jeong, Jin-Woo; Lee, Dae-Sung; Yim, Mi-Jin; Lee, Jeong Min; Han, Min Ho; Kim, Suhkmann; Kim, Heui-Soo; Kim, Gi-Young; Park, Eui Kyun; Jeon, You-Jin; Cha, Hee-Jae; Choi, Yung Hyun

doi:10.3390/ijms19082308

Open AccessArticle

RETRACTED: Sargassum serratifolium Extract Attenuates Interleukin-1β-Induced Oxidative Stress and Inflammatory Response in Chondrocytes by Suppressing the Activation of NF-κB, p38 MAPK, and PI3K/Akt

by

Cheol Park

^1,†,

Jin-Woo Jeong

^2,†,

Dae-Sung Lee

³,

Mi-Jin Yim

³,

Jeong Min Lee

³,

Min Ho Han

³,

Suhkmann Kim

⁴,

Heui-Soo Kim

⁵,

Gi-Young Kim

⁶

,

Eui Kyun Park

⁷

,

You-Jin Jeon

⁶

,

Hee-Jae Cha

^8,*

and

Yung Hyun Choi

^9,10,*

¹

Department of Molecular Biology, College of Natural Sciences, Dong-eui University, Busan 47340, Korea

²

Freshwater Bioresources Utilization Bureau, Nakdonggang National Institute of Biological Resources, Sangju 37242, Korea

³

National Marine Biodiversity Institute of Korea, Seocheon 33662, Korea

⁴

Department of Chemistry, College of Natural Sciences, Center for Proteome Biophysics and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, Korea

⁵

Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 46241, Korea

⁶

Department of Marine Life Sciences, School of Marine Biomedical Sciences, Jeju National University, Jeju 63243, Korea

⁷

Department of Oral Pathology and Regenerative Medicine, School of Dentistry, Institute for Hard Tissue and Biotooth Regeneration, Kyungpook National University, Daegu 41940, Korea

⁸

Department of Parasitology and Genetics, College of Medicine, Kosin University, Busan 49267, Korea

⁹

Anti-Aging Research Center and Blue-Bio Industry RIC, Dong-eui University, Busan 47227, Korea

¹⁰

Department of Biochemistry, College of Korean Medicine, Dong-eui University, Busan 47227, Korea

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2018, 19(8), 2308; https://doi.org/10.3390/ijms19082308

Submission received: 17 July 2018 / Accepted: 1 August 2018 / Published: 7 August 2018 / Retracted: 1 July 2026

(This article belongs to the Special Issue Natural Anti-Inflammatory Agents 2018)

Download

Browse Figures

Abstract

Osteoarthritis (OA) is a degenerative joint disease that is characterized by irreversible articular cartilage destruction by inflammatory reaction. Among inflammatory stimuli, interleukin-1β (IL-1β) is known to play a crucial role in OA pathogenesis by stimulating several mediators that contribute to cartilage degradation. Recently, the marine brown alga Sargassum serratifolium has been reported to exhibit antioxidant and anti-inflammatory effects in microglial and human umbilical vein endothelial cell models using lipopolysaccharide and tumor necrosis factor-α, but its beneficial effects on OA have not been investigated. This study aimed to evaluate the anti-osteoarthritic effects of ethanol extract of S. serratifolium (EESS) in SW1353 human chondrocytes and, in parallel, primary rat articular chondrocytes. Our results showed that EESS effectively blocked the generation of reactive oxygen species in IL-1β-treated SW1353 and rat primary chondrocytes, indicating that EESS has a potent antioxidant activity. EESS also attenuated IL-1β-induced production of nitric oxide (NO) and prostaglandin E₂, major inflammatory mediators in these cells, which was associated with the inhibition of inducible NO synthase and cyclooxygenase-2 expression. Moreover, EESS downregulated the level of gene expression of matrix metalloproteinase (MMP)-1, -3 and -13 in SW1353 chondrocytes treated with IL-1β, resulting in their extracellular secretion reduction. In addition, the IL-1β-induced activation of nuclear factor-kappa B (NF-κB) was restored by EESS. Furthermore, EESS reduced the activation of p38 mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathways upon IL-1β stimulation. These results indicate that EESS has the potential to exhibit antioxidant and anti-inflammatory effects through inactivation of the NF-κB, p38 MAPK, and PI3K/Akt signaling pathways. Collectively, these findings demonstrate that EESS may have the potential for chondroprotection, and extracts of S. serratifolium could potentially be used in the prevention and treatment of OA.

Keywords: Sargassum serratifolium; chondrocytes; inflammation; ROS; NF-κB; MAPKs; PI3K/Akt

Graphical Abstract

Share and Cite

MDPI and ACS Style

Park, C.; Jeong, J.-W.; Lee, D.-S.; Yim, M.-J.; Lee, J.M.; Han, M.H.; Kim, S.; Kim, H.-S.; Kim, G.-Y.; Park, E.K.; et al. RETRACTED: Sargassum serratifolium Extract Attenuates Interleukin-1β-Induced Oxidative Stress and Inflammatory Response in Chondrocytes by Suppressing the Activation of NF-κB, p38 MAPK, and PI3K/Akt. Int. J. Mol. Sci. 2018, 19, 2308. https://doi.org/10.3390/ijms19082308

AMA Style

Park C, Jeong J-W, Lee D-S, Yim M-J, Lee JM, Han MH, Kim S, Kim H-S, Kim G-Y, Park EK, et al. RETRACTED: Sargassum serratifolium Extract Attenuates Interleukin-1β-Induced Oxidative Stress and Inflammatory Response in Chondrocytes by Suppressing the Activation of NF-κB, p38 MAPK, and PI3K/Akt. International Journal of Molecular Sciences. 2018; 19(8):2308. https://doi.org/10.3390/ijms19082308

Chicago/Turabian Style

Park, Cheol, Jin-Woo Jeong, Dae-Sung Lee, Mi-Jin Yim, Jeong Min Lee, Min Ho Han, Suhkmann Kim, Heui-Soo Kim, Gi-Young Kim, Eui Kyun Park, and et al. 2018. "RETRACTED: Sargassum serratifolium Extract Attenuates Interleukin-1β-Induced Oxidative Stress and Inflammatory Response in Chondrocytes by Suppressing the Activation of NF-κB, p38 MAPK, and PI3K/Akt" International Journal of Molecular Sciences 19, no. 8: 2308. https://doi.org/10.3390/ijms19082308

APA Style

Park, C., Jeong, J.-W., Lee, D.-S., Yim, M.-J., Lee, J. M., Han, M. H., Kim, S., Kim, H.-S., Kim, G.-Y., Park, E. K., Jeon, Y.-J., Cha, H.-J., & Choi, Y. H. (2018). RETRACTED: Sargassum serratifolium Extract Attenuates Interleukin-1β-Induced Oxidative Stress and Inflammatory Response in Chondrocytes by Suppressing the Activation of NF-κB, p38 MAPK, and PI3K/Akt. International Journal of Molecular Sciences, 19(8), 2308. https://doi.org/10.3390/ijms19082308

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

RETRACTED: Sargassum serratifolium Extract Attenuates Interleukin-1β-Induced Oxidative Stress and Inflammatory Response in Chondrocytes by Suppressing the Activation of NF-κB, p38 MAPK, and PI3K/Akt

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI