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Int. J. Mol. Sci. 2018, 19(8), 2283; https://doi.org/10.3390/ijms19082283

Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine

The State Key Laboratory of Refractories and Metallurgy, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China
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Received: 24 June 2018 / Revised: 23 July 2018 / Accepted: 30 July 2018 / Published: 3 August 2018
(This article belongs to the Special Issue Nucleic Acid Nanotechnology)
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Abstract

Due to the addressability and programmability, DNA has been applied not merely in constructing static elegant nanostructures such as two dimensional and three dimensional DNA nanostructures but also in designing dynamic nanodevices. Moreover, DNA could combine with hydrophobic organic molecules to be a new amphiphilic building block and then self-assemble into nanomaterials. Of particular note, a recent state-of-the-art research has turned our attention to the amphiphilic DNA organic hybrids including small molecule modified DNA (lipid-DNA, fluorescent molecule-DNA, etc.), DNA block copolymers, and DNA-dendron hybrids. This review focuses mainly on the development of their self-assembly behavior and their potential application in nanomaterial and biomedicine. The potential challenges regarding of the amphiphilic DNA organic hybrids are also briefly discussed, aiming to advance their practical applications in nanoscience and biomedicine. View Full-Text
Keywords: small molecule modified DNA; DNA block copolymers; DNA-dendron hybrids; self-assembly; nanostructure; nanoscience; biomedicine small molecule modified DNA; DNA block copolymers; DNA-dendron hybrids; self-assembly; nanostructure; nanoscience; biomedicine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Zhao, Z.; Du, T.; Liang, F.; Liu, S. Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine. Int. J. Mol. Sci. 2018, 19, 2283.

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