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Int. J. Mol. Sci. 2018, 19(7), 1987; https://doi.org/10.3390/ijms19071987

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data

R&D Skin Biology; 4122 Factoria Boulevard SE, Suite Number 200, Bellevue, WA 98006, USA
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Received: 18 May 2018 / Revised: 25 June 2018 / Accepted: 2 July 2018 / Published: 7 July 2018
(This article belongs to the Special Issue Peptides for Health Benefits)
Full-Text   |   PDF [234 KB, uploaded 7 July 2018]

Abstract

The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts. GHK’s ability to improve tissue repair has been demonstrated for skin, lung connective tissue, boney tissue, liver, and stomach lining. GHK has also been found to possess powerful cell protective actions, such as multiple anti-cancer activities and anti-inflammatory actions, lung protection and restoration of chronic obstructive pulmonary disease (COPD) fibroblasts, suppression of molecules thought to accelerate the diseases of aging such as NFκB, anti-anxiety, anti-pain and anti-aggression activities, DNA repair, and activation of cell cleansing via the proteasome system. Recent genetic data may explain such diverse protective and healing actions of one molecule, revealing multiple biochemical pathways regulated by GHK. View Full-Text
Keywords: GHK; GHK-Cu; gene profiling; wound healing; COPD; skin regeneration; anti-oxidant; fibrinogen GHK; GHK-Cu; gene profiling; wound healing; COPD; skin regeneration; anti-oxidant; fibrinogen
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Pickart, L.; Margolina, A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int. J. Mol. Sci. 2018, 19, 1987.

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