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PPARs and Energy Metabolism Adaptation during Neurogenesis and Neuronal Maturation

Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(7), 1869;
Received: 7 May 2018 / Revised: 20 June 2018 / Accepted: 24 June 2018 / Published: 26 June 2018
(This article belongs to the Special Issue PPARs in Cellular and Whole Body Energy Metabolism)
Peroxisome proliferator activated receptors (PPARs) are a class of ligand-activated transcription factors, belonging to the superfamily of receptors for steroid and thyroid hormones, retinoids, and vitamin D. PPARs control the expression of several genes connected with carbohydrate and lipid metabolism, and it has been demonstrated that PPARs play important roles in determining neural stem cell (NSC) fate. Lipogenesis and aerobic glycolysis support the rapid proliferation during neurogenesis, and specific roles for PPARs in the control of different phases of neurogenesis have been demonstrated. Understanding the changes in metabolism during neuronal differentiation is important in the context of stem cell research, neurodegenerative diseases, and regenerative medicine. In this review, we will discuss pivotal evidence that supports the role of PPARs in energy metabolism alterations during neuronal maturation and neurodegenerative disorders. View Full-Text
Keywords: stem cells; metabolism; PPARs stem cells; metabolism; PPARs
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D’Angelo, M.; Antonosante, A.; Castelli, V.; Catanesi, M.; Moorthy, N.; Iannotta, D.; Cimini, A.; Benedetti, E. PPARs and Energy Metabolism Adaptation during Neurogenesis and Neuronal Maturation. Int. J. Mol. Sci. 2018, 19, 1869.

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