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Open AccessReview

Insights into the Role of PPARβ/δ in NAFLD

by Jiapeng Chen 1,2, Alexandra Montagner 3,4, Nguan Soon Tan 1,2,5,6 and Walter Wahli 1,3,7,*
Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore 308232, Singapore
School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
ToxAlim, Research Center in Food Toxicology, National Institute for Agricultural Research (INRA), 180 Chemin de Tournefeuille, 31300 Toulouse, France
Institut National de La Santé et de La Recherche Médicale (INSERM), UMR1048, Institute of Metabolic and Cardiovascular Diseases, 31027 Toulouse, France
KK Research Centre, KK Women’s and Children Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore
Institute of Molecular and Cell Biology, Agency for Science Technology & Research, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore
Center for Integrative Genomics, University of Lausanne, Génopode, CH-1015 Lausanne, Switzerland
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(7), 1893;
Received: 15 May 2018 / Revised: 13 June 2018 / Accepted: 23 June 2018 / Published: 27 June 2018
(This article belongs to the Special Issue PPARs in Cellular and Whole Body Energy Metabolism)
Non-alcoholic fatty liver disease (NAFLD) is a major health issue in developed countries. Although usually associated with obesity, NAFLD is also diagnosed in individuals with low body mass index (BMI) values, especially in Asia. NAFLD can progress from steatosis to non-alcoholic steatohepatitis (NASH), which is characterized by liver damage and inflammation, leading to cirrhosis and hepatocellular carcinoma (HCC). NAFLD development can be induced by lipid metabolism alterations; imbalances of pro- and anti-inflammatory molecules; and changes in various other factors, such as gut nutrient-derived signals and adipokines. Obesity-related metabolic disorders may be improved by activation of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)β/δ, which is involved in metabolic processes and other functions. This review is focused on research findings related to PPARβ/δ-mediated regulation of hepatic lipid and glucose metabolism and NAFLD development. It also discusses the potential use of pharmacological PPARβ/δ activation for NAFLD treatment. View Full-Text
Keywords: PPARβ/δ; NAFLD; NASH; steatosis; liver; lipid metabolism PPARβ/δ; NAFLD; NASH; steatosis; liver; lipid metabolism
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Chen, J.; Montagner, A.; Tan, N.S.; Wahli, W. Insights into the Role of PPARβ/δ in NAFLD. Int. J. Mol. Sci. 2018, 19, 1893.

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