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Molecular Mechanisms for Regulating Postnatal Ductus Arteriosus Closure

by Yu-Chi Hung 1,2, Jwu-Lai Yeh 1,3,4,5 and Jong-Hau Hsu 1,3,6,7,*
1
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
Department of Pediatrics, St. Joseph Hospital, Kaohsiung 807, Taiwan
3
Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
5
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
6
Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
7
Department of Pediatrics, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(7), 1861; https://doi.org/10.3390/ijms19071861
Received: 4 May 2018 / Revised: 30 May 2018 / Accepted: 20 June 2018 / Published: 25 June 2018
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The ductus arteriosus (DA) connects the main pulmonary artery and the aorta in fetal circulation and closes spontaneously within days after birth in normal infants. Abnormal patent DA (PDA) causes morbidities and mortality, especially in preterm infants. Closure of the DA is a complex interactive process involving two events: functional and anatomic closure. Functional closure by smooth muscle contraction was achieved through the regulatory factors of vaso-reactivity. These factors include oxygen sensing system, glutamate, osmolality, prostaglandin E2, nitric oxide, and carbon monoxide. Anatomic closure by vascular remodeling involved several vascular components including endothelium, extracellular matrix, smooth muscle cells, and intraluminal blood cells. Despite advances in understanding of PDA pathogenesis, the molecular mechanism for regulation of DA closure is complex and not fully understood. In this article we review recent evidence regarding the molecular mechanisms of DA closure. View Full-Text
Keywords: ductus arteriosus; endothelial cells; extracellular matrix; smooth muscle cells; vascular remodeling ductus arteriosus; endothelial cells; extracellular matrix; smooth muscle cells; vascular remodeling
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MDPI and ACS Style

Hung, Y.-C.; Yeh, J.-L.; Hsu, J.-H. Molecular Mechanisms for Regulating Postnatal Ductus Arteriosus Closure. Int. J. Mol. Sci. 2018, 19, 1861.

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