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Int. J. Mol. Sci. 2018, 19(6), 1769; https://doi.org/10.3390/ijms19061769

Synergistic Antitumor Effect of Oligogalacturonides and Cisplatin on Human Lung Cancer A549 Cells

1
Department of Food Science, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan
2
Department of Leisure, Recreation and Tourism Management, Tzu Hui Institute of Technology, Pingtung 92601, Taiwan
3
Department of Food Technology, Bina Nusantara University, Alam Sutera Campus, Alam Sutera, Tangerang 15143, Indonesia
4
Life Science Center, Hsing Wu University, LinKou District, New Taipei City 24452, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 8 May 2018 / Revised: 7 June 2018 / Accepted: 12 June 2018 / Published: 14 June 2018
(This article belongs to the Special Issue Natural Bioactives and Phytochemicals in Cancer Prevention)
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Abstract

Cisplatin (DPP), a clinically potent antineoplastic agent, is limited by its severe adverse effects. The aim of this study was to investigate the effect of oligogalacturonides (OGA) and DDP on human lung cancer A549 cells. The combined use of OGA and DDP had a synergistic effect on the growth inhibition of A549 cells, changed the cell cycle distribution, and enhanced apoptotic response, especially in sequential combination treatment group of DDP 12 h + OGA 12 h. Western blot analyses showed that the combination treatment of OGA and DDP upregulated Bax, p53, and Caspase-3 and downregulated Bcl-2 proteins. More importantly, DDP-induced toxicity was attenuated by OGA and DDP combination treatment in normal HEK293 cells. Our data suggests that the combined use of OGA from natural sources and DDP could be an important new adjuvant therapy for lung cancer as well as offer important insights for reducing kidney toxicity of DDP and delaying the development of DDP resistance. View Full-Text
Keywords: cisplatin; oligogalacturonides; synergistic effect; adjuvant therapy cisplatin; oligogalacturonides; synergistic effect; adjuvant therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Huang, C.-S.; Huang, A.-C.; Huang, P.-H.; Lo, D.; Wang, Y.-T.; Wu, M.-C. Synergistic Antitumor Effect of Oligogalacturonides and Cisplatin on Human Lung Cancer A549 Cells. Int. J. Mol. Sci. 2018, 19, 1769.

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