Next Article in Journal
The Multifaceted Role of STAT3 in Mammary Gland Involution and Breast Cancer
Next Article in Special Issue
Translocator Protein (TSPO) as a Potential Biomarker in Human Cancers
Previous Article in Journal
Isobavachalcone from Angelica keiskei Inhibits Adipogenesis and Prevents Lipid Accumulation
Previous Article in Special Issue
Delivery of Proapoptotic Agents in Glioma Cell Lines by TSPO Ligand–Dextran Nanogels
Open AccessReview

TSPO: An Evolutionarily Conserved Protein with Elusive Functions

Department of Neurosurgery, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(6), 1694; https://doi.org/10.3390/ijms19061694
Received: 15 May 2018 / Accepted: 18 May 2018 / Published: 7 June 2018
TSPO (18 kDa translocator protein) was identified decades ago in a search for peripheral tissue binding sites for benzodiazepines, and was formerly called the peripheral benzodiazepine receptor. TSPO is a conserved protein throughout evolution and it is implicated in the regulation of many cellular processes, including inflammatory responses, oxidative stress, and mitochondrial homeostasis. TSPO, apart from its broad expression in peripheral tissues, is highly expressed in neuroinflammatory cells, such as activated microglia. In addition, emerging studies employing the ligands of TSPO suggest that TSPO plays an important role in neuropathological settings as a biomarker and therapeutic target. However, the precise molecular function of this protein in normal physiology and neuropathology remains enigmatic. This review provides an overview of recent advances in our understanding of this multifaceted molecule and identifies the knowledge gap in the field for future functional studies. View Full-Text
Keywords: TSPO; 18 kDa translocator protein; steroidogenesis; glial activation; neuroimaging TSPO; 18 kDa translocator protein; steroidogenesis; glial activation; neuroimaging
Show Figures

Figure 1

MDPI and ACS Style

Bonsack, F.; Sukumari-Ramesh, S. TSPO: An Evolutionarily Conserved Protein with Elusive Functions. Int. J. Mol. Sci. 2018, 19, 1694.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop