Next Article in Journal
Effects of Cyclic Mechanical Stretch on the Proliferation of L6 Myoblasts and Its Mechanisms: PI3K/Akt and MAPK Signal Pathways Regulated by IGF-1 Receptor
Previous Article in Journal
Signal Transduction in Plant–Nematode Interactions
Previous Article in Special Issue
Overview of Cadmium Thyroid Disrupting Effects and Mechanisms
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessReview

Current Knowledge on Endocrine Disrupting Chemicals (EDCs) from Animal Biology to Humans, from Pregnancy to Adulthood: Highlights from a National Italian Meeting

1
Department of Obstetrics, Gynaecology and Paediatrics, Azienda USL-IRCCS, Viale Risorgimento 80, 42123 Reggio Emilia, Italy
2
Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
3
Former Department of Medicine, University of Parma, Via A. Catalani 10, 43123 Parma, Italy
4
ECERI European Cancer and Environment Research Institute, Square de Meeus, 38-40, 1000 Bruxelles, Belgium
5
Pediatric Endocrinology Programme, Pediatrics Unit, Department of Woman, Child Health and Urologic Diseases, AOU S. Orsola-Malpighi, Via Massarenti, 11, 40138 Bologna, Italy
6
Department of Pediatrics (DPUO), Bambino Gesù Children’s Hospital, Tor Vergata University, Piazza S. Onofrio 4, 00165 Rome, Italy
7
Department of Pediatrics and Neonatology, Augusto Murri Hospital, Via Augusto Murri, 17, 63900 Fermo, Itlay
8
Neonatal Intensive Care Unit, Neonatal Pathology and Neonatal Section, AOU and University of Cagliari, via Ospedale, 54, 09124 Cagliari, Italy
9
Villa Santa Maria Institute, Neuropsychiatric Rehabilitation Center, Via IV Novembre 15, 22038 Tavernerio (Como), Italy
10
Department of Medical and Surgical Sciences of the Mother, Children and Adults, Pediatrics Unit, University of Modena and Reggio Emilia, via del Pozzo, 71, 41124 Modena, Italy
11
Department of Veterinary Public Health and Food Safety, Food and Veterinary Toxicology Unit ISS–National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy
12
Department of Traslational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma, 55, 56123 Pisa, Italy
13
Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Via Gramsci, 14, 43126 Parma, Italy
14
Laboratory of Neuroendocrinology, Department of Neuroscience Rita Levi Montalcini, University of Turin, Via Cherasco 15, 10126 Turin, Italy
15
Neuroscience Institute Cavalieri-Ottolenghi (NICO), Regione Gonzole, 10, 10043 Orbassano (Turin), Italy
16
Department of Chemistry ‘Ugo Schiff’, University of Florence, Via della Lastruccia, 3-13, 50019 Sesto Fiorentino, Florence, Italy
17
Unit of Evolutionary and Functional Biology—Department of Chemistry, Life Sciences and Environmental Sustainability (SCVSA)-University of Parma–11/a, 43124 Parma, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(6), 1647; https://doi.org/10.3390/ijms19061647
Received: 16 April 2018 / Revised: 23 May 2018 / Accepted: 31 May 2018 / Published: 2 June 2018
(This article belongs to the Special Issue Advances in the Research of Endocrine Disrupting Chemicals)
  |  
PDF [3779 KB, uploaded 2 June 2018]
  |  

Abstract

Wildlife has often presented and suggested the effects of endocrine disrupting chemicals (EDCs). Animal studies have given us an important opportunity to understand the mechanisms of action of many chemicals on the endocrine system and on neurodevelopment and behaviour, and to evaluate the effects of doses, time and duration of exposure. Although results are sometimes conflicting because of confounding factors, epidemiological studies in humans suggest effects of EDCs on prenatal growth, thyroid function, glucose metabolism and obesity, puberty, fertility, and on carcinogenesis mainly through epigenetic mechanisms. This manuscript reviews the reports of a multidisciplinary national meeting on this topic. View Full-Text
Keywords: Endocrine Disrupting Chemicals (EDCs); neurodevelopment; autism; obesity; puberty; fertility; thyroid function; epigenetics; carcinogenesis; growth Endocrine Disrupting Chemicals (EDCs); neurodevelopment; autism; obesity; puberty; fertility; thyroid function; epigenetics; carcinogenesis; growth
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Street, M.E.; Angelini, S.; Bernasconi, S.; Burgio, E.; Cassio, A.; Catellani, C.; Cirillo, F.; Deodati, A.; Fabbrizi, E.; Fanos, V.; Gargano, G.; Grossi, E.; Iughetti, L.; Lazzeroni, P.; Mantovani, A.; Migliore, L.; Palanza, P.; Panzica, G.; Papini, A.M.; Parmigiani, S.; Predieri, B.; Sartori, C.; Tridenti, G.; Amarri, S. Current Knowledge on Endocrine Disrupting Chemicals (EDCs) from Animal Biology to Humans, from Pregnancy to Adulthood: Highlights from a National Italian Meeting. Int. J. Mol. Sci. 2018, 19, 1647.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top