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Int. J. Mol. Sci. 2018, 19(5), 1466;

Cytoprotective Effect of Epigallocatechin Gallate (EGCG)-5′-O-α-Glucopyranoside, a Novel EGCG Derivative

Department of Integrative Biotechnology and Biomedical Institute for Convergence (BICS), Sungkyunkwan University, Suwon 16419, Korea
Basic Research & Innovation Division, Amorepacific Corporation R&D Center, Yongin 17074, Korea
Department of Biomedical Engineering, Khulna University of Engineering and Technology, Khulna 9203, Bangladesh
Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang 25354, Korea
Department of Engineering Chemistry, Chungbuk National University, Cheongju 28644, Korea
There authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 31 March 2018 / Revised: 8 May 2018 / Accepted: 11 May 2018 / Published: 15 May 2018
(This article belongs to the Section Bioactives and Nutraceuticals)
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Epigallocatechin gallate (EGCG) is a well-studied polyphenol with antioxidant effects. Since EGCG has low solubility and stability, many researchers have modified EGCG residues to ameliorate these problems. A novel EGCG derivative, EGCG-5′-O-α-glucopyranoside (EGCG-5′Glu), was synthesized, and its characteristics were investigated. EGCG-5′Glu showed antioxidant effects in cell and cell-free systems. Under SNP-derived radical exposure, EGCG-5′Glu decreased nitric oxide (NO) production, and recovered ROS-mediated cell viability. Moreover, EGCG-5′Glu regulated apoptotic pathways (caspases) and cell survival molecules (phosphoinositide 3-kinase (PI3K) and phosphoinositide-dependent kinase 1 (PDK1)). In another radical-induced condition, ultraviolet B (UVB) irradiation, EGCG-5′Glu protected cells from UVB and regulated the PI3K/PDK1/AKT pathway. Next, the proliferative effect of EGCG-5′Glu was examined. EGCG-5′Glu increased cell proliferation by modulating nuclear factor (NF)-κB activity. EGCG-5′Glu protects and repairs cells from external damage via its antioxidant effects. These results suggest that EGCG-5′Glu could be used as a cosmetics ingredient or dietary supplement. View Full-Text
Keywords: epigallocatechin gallate derivate; antioxidant; free radicals; cell survival; apoptosis epigallocatechin gallate derivate; antioxidant; free radicals; cell survival; apoptosis

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Han, S.Y.; Kim, E.; Hwang, K.; Ratan, Z.A.; Hwang, H.; Kim, E.-M.; Kim, D.; Park, J.; Cho, J.Y. Cytoprotective Effect of Epigallocatechin Gallate (EGCG)-5′-O-α-Glucopyranoside, a Novel EGCG Derivative. Int. J. Mol. Sci. 2018, 19, 1466.

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