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T Cell Calcium Signaling Regulation by the Co-Receptor CD5

Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84604, USA
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(5), 1295; https://doi.org/10.3390/ijms19051295
Received: 27 February 2018 / Revised: 19 April 2018 / Accepted: 24 April 2018 / Published: 26 April 2018
(This article belongs to the Special Issue Calcium Signaling in Human Health and Diseases)
Calcium influx is critical for T cell effector function and fate. T cells are activated when T cell receptors (TCRs) engage peptides presented by antigen-presenting cells (APC), causing an increase of intracellular calcium (Ca2+) concentration. Co-receptors stabilize interactions between the TCR and its ligand, the peptide-major histocompatibility complex (pMHC), and enhance Ca2+ signaling and T cell activation. Conversely, some co-receptors can dampen Ca2+ signaling and inhibit T cell activation. Immune checkpoint therapies block inhibitory co-receptors, such as cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), to increase T cell Ca2+ signaling and promote T cell survival. Similar to CTLA-4 and PD-1, the co-receptor CD5 has been known to act as a negative regulator of T cell activation and to alter Ca2+ signaling and T cell function. Though much is known about the role of CD5 in B cells, recent research has expanded our understanding of CD5 function in T cells. Here we review these recent findings and discuss how our improved understanding of CD5 Ca2+ signaling regulation could be useful for basic and clinical research. View Full-Text
Keywords: calcium signaling; T cell receptor (TCR); co-receptors; CD-5; PD-1; CTL-4 calcium signaling; T cell receptor (TCR); co-receptors; CD-5; PD-1; CTL-4
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MDPI and ACS Style

Freitas, C.M.T.; Johnson, D.K.; Weber, K.S. T Cell Calcium Signaling Regulation by the Co-Receptor CD5. Int. J. Mol. Sci. 2018, 19, 1295. https://doi.org/10.3390/ijms19051295

AMA Style

Freitas CMT, Johnson DK, Weber KS. T Cell Calcium Signaling Regulation by the Co-Receptor CD5. International Journal of Molecular Sciences. 2018; 19(5):1295. https://doi.org/10.3390/ijms19051295

Chicago/Turabian Style

Freitas, Claudia M.T.; Johnson, Deborah K.; Weber, K. S. 2018. "T Cell Calcium Signaling Regulation by the Co-Receptor CD5" Int. J. Mol. Sci. 19, no. 5: 1295. https://doi.org/10.3390/ijms19051295

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