Next Article in Journal
PIN7 Auxin Carrier Has a Preferential Role in Terminating Radial Root Expansion in Arabidopsis thaliana
Next Article in Special Issue
T Cell Calcium Signaling Regulation by the Co-Receptor CD5
Previous Article in Journal
CD9 and CD81 Interactions and Their Structural Modelling in Sperm Prior to Fertilization
Previous Article in Special Issue
Opposing Roles of Calcium and Intracellular ATP on Gating of the Purinergic P2X2 Receptor Channel
Open AccessReview

Calcium and Nuclear Signaling in Prostate Cancer

Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 955 Main Street, Buffalo, NY 14203, USA
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(4), 1237;
Received: 16 March 2018 / Revised: 15 April 2018 / Accepted: 17 April 2018 / Published: 19 April 2018
(This article belongs to the Special Issue Calcium Signaling in Human Health and Diseases)
Recently, there have been a number of developments in the fields of calcium and nuclear signaling that point to new avenues for a more effective diagnosis and treatment of prostate cancer. An example is the discovery of new classes of molecules involved in calcium-regulated nuclear import and nuclear calcium signaling, from the G protein-coupled receptor (GPCR) and myosin families. This review surveys the new state of the calcium and nuclear signaling fields with the aim of identifying the unifying themes that hold out promise in the context of the problems presented by prostate cancer. Genomic perturbations, kinase cascades, developmental pathways, and channels and transporters are covered, with an emphasis on nuclear transport and functions. Special attention is paid to the molecular mechanisms behind prostate cancer progression to the malignant forms and the unfavorable response to anti-androgen treatment. The survey leads to some new hypotheses that connect heretofore disparate results and may present a translational interest. View Full-Text
Keywords: metastasis; nuclear import; myosin IC; calcium; prostate cancer metastasis; nuclear import; myosin IC; calcium; prostate cancer
Show Figures

Graphical abstract

MDPI and ACS Style

Maly, I.V.; Hofmann, W.A. Calcium and Nuclear Signaling in Prostate Cancer. Int. J. Mol. Sci. 2018, 19, 1237.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop