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Int. J. Mol. Sci. 2018, 19(3), 670; https://doi.org/10.3390/ijms19030670

Current Insights into Oral Cancer Epigenetics

1
Department of Prosthetic Dentistry and Dental Materials, Division Dental Propaedeutics, Aesthetics, Faculty of Dentistry, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400001 Cluj-Napoca, Romania
2
MEDFUTURE—Research Center for Advanced Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Marinescu 23 Street, 400001 Cluj-Napoca, Romania
3
Department of Medical Biology, Faculty of Medicine, Medical University-Plovdiv, 15-А Vassil Aprilov Blvd., 4000 Plovdiv, Bulgaria
4
Technological Center for Emergency Medicine, 15-АVassil Aprilov Blvd., 4000 Plovdiv, Bulgaria
5
Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 05-552 Jastrzebiec, Poland
6
Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria
7
Research Center for Functional Genomics, Biomedicine and Translational Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Marinescu 23 Street, 400337 Cluj-Napoca, Romania
8
Department of Functional Genomics and Experimental Pathology, The Oncology Institute “Prof. Dr. Ion Chiricuţă”, 400015 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
Received: 30 January 2018 / Revised: 20 February 2018 / Accepted: 22 February 2018 / Published: 27 February 2018
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Full-Text   |   PDF [4498 KB, uploaded 27 February 2018]   |  

Abstract

Epigenetic modifications have emerged into one of the cancer hallmarks, replacing the concept of malignant pathologies as being solely genetic-based conditions. The epigenetic landscape is responsible for normal development but also for the heterogeneity among tissues in terms of gene expression patterns. Dysregulation in these mechanisms has been associated with disease stage, and increased attention is now granted to cancer in order to take advantage of these modifications in terms of novel therapeutic strategies or diagnosis/prognosis tools. Oral cancer has also been subjected to epigenetic analysis with numerous studies revealing that the development and progression of this malignancy are partially induced by an altered epigenetic substrate together with genetic alterations and prolonged exposure to environmental risk factors. The present review summarizes the most important epigenetic modifications associated with oral cancer and also their potential to be used as new therapeutic targets. View Full-Text
Keywords: oral cancer; epigenetics; DNA methylation; histone; miRNA; non-coding RNAs oral cancer; epigenetics; DNA methylation; histone; miRNA; non-coding RNAs
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Irimie, A.I.; Ciocan, C.; Gulei, D.; Mehterov, N.; Atanasov, A.G.; Dudea, D.; Berindan-Neagoe, I. Current Insights into Oral Cancer Epigenetics. Int. J. Mol. Sci. 2018, 19, 670.

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