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Int. J. Mol. Sci. 2018, 19(2), 627; https://doi.org/10.3390/ijms19020627

“Nano-Ginseng” for Enhanced Cytotoxicity AGAINST Cancer Cells

1
Tianjin Key Laboratory of Pulp and Paper, College of Papermaking Science and Technology, Tianjin University of Science and Technology, Tianjin 300457, China
2
Beijing Key Laboratory of Lignocellulosic Chemistry, College of Materials Science and Technology, Beijing Forestry University, Beijing 100083, China
*
Authors to whom correspondence should be addressed.
Received: 23 January 2018 / Revised: 6 February 2018 / Accepted: 11 February 2018 / Published: 23 February 2018
(This article belongs to the Collection Bioactive Nanoparticles)
Full-Text   |   PDF [3133 KB, uploaded 23 February 2018]   |  

Abstract

Panax ginseng has high medicinal and health values. However, the various and complex components of ginseng may interact with each other, thus reducing and even reversing therapeutic effects. In this study, we designed and fabricated a novel “nano-ginseng” with definite ingredients, ginsenoside Rb1/protopanaxadiol nanoparticles (Rb1/PPD NPs), completely based on the protopanaxadiol-type extracts. The optimized nano-formulations demonstrated an appropriate size (~110 nm), high drug loading efficiency (~96.8%) and capacity (~27.9 wt %), long half-time in systemic circulation (nine-fold longer than free PPD), better antitumor effects in vitro and in vivo, higher accumulation at the tumor site and reduced damage to normal tissues. Importantly, this process of “nano-ginseng” production is a simple, scalable, green economy process. View Full-Text
Keywords: nanoparticle; drug delivery; self-assemble; anticancer; green process nanoparticle; drug delivery; self-assemble; anticancer; green process
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Dai, L.; Zhu, W.; Si, C.; Lei, J. “Nano-Ginseng” for Enhanced Cytotoxicity AGAINST Cancer Cells. Int. J. Mol. Sci. 2018, 19, 627.

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