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Int. J. Mol. Sci. 2018, 19(2), 613;

Anti-Renal Fibrotic Effect of Exercise Training in Hypertension

Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung 40402, Taiwan
College of Medicine, China Medical University, Taichung 40402, Taiwan
Graduate Program of Translational Medicine, China Medical University, Taichung 40402, Taiwan
Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan
Department of Sports Sciences, University of Taipei, Taipei 11153, Taiwan
Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taichung 40402, Taiwan
Department of Occupational Therapy, Asia University, Taichung 41354, Taiwan
School of Rehabilitation Science, Shanghai University of TCM, Shanghai 201203, China
Author to whom correspondence should be addressed.
Received: 9 January 2018 / Revised: 7 February 2018 / Accepted: 13 February 2018 / Published: 20 February 2018
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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The purpose of this study was to evaluate the effects of exercise training on renal fibrosis in hypertensive rats. Masson’s trichrome staining and Western blotting were performed on the excised renal cortex from sixteen male spontaneously hypertensive rats (SHR), which were randomly divided into either a sedentary hypertensive group (SHR) or exercise hypertensive group (SHR-EX, running on an exercise treadmill for 60 min/day, 5 sessions/week, for 12 weeks), and from eight male Wistar-Kyoto rats which served as a sedentary normotensive group (WKY). The systolic blood pressure (SBP) and renal fibrosis in hypertensive rats improved after exercise training. The inflammatory-related protein levels of interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2), as well as the fibrotic-related protein levels of transforming growth factor-beta (TGF-β), phospho-Smad2/3 (p-Smad2/3), connective tissue growth factor (CTGF), matrix metalloproteinase-9 (MMP-9), and matrix metalloproteinase-2 (MMP-2) were decreased in the SHR-EX group when compared with the SHR group. Exercise training suppressed the hypertension-induced renal cortical inflammatory and fibrotic pathways in hypertensive rat models. These findings might indicate a new therapeutic effect for exercise training to prevent renal fibrosis in hypertensive nephropathy. View Full-Text
Keywords: fibrosis; hypertension; inflammation; treadmill training fibrosis; hypertension; inflammation; treadmill training

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Huang, C.-C.; Lin, Y.-Y.; Yang, A.-L.; Kuo, T.-W.; Kuo, C.-H.; Lee, S.-D. Anti-Renal Fibrotic Effect of Exercise Training in Hypertension. Int. J. Mol. Sci. 2018, 19, 613.

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