Next Article in Journal
Multifaceted Mechanisms of Cisplatin Resistance in Long-Term Treated Urothelial Carcinoma Cell Lines
Next Article in Special Issue
Annexin A1: Uncovering the Many Talents of an Old Protein
Previous Article in Journal
Peripheral B-Cell Subset Distribution in Primary Antiphospholipid Syndrome
Previous Article in Special Issue
Ac2-26, an Annexin A1 Peptide, Attenuates Ischemia-Reperfusion-Induced Acute Lung Injury
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(2), 591;

Functional Association between Regulatory RNAs and the Annexins

Urology Research Laboratory, Department for BioMedical Research, University of Bern, 3008 Bern, Switzerland
Received: 6 January 2018 / Revised: 12 February 2018 / Accepted: 14 February 2018 / Published: 16 February 2018
Full-Text   |   PDF [2446 KB, uploaded 19 February 2018]   |  


Cells respond to pathophysiological states by activation of stress-induced signalling. Regulatory non-coding microRNAs (miRNAs) often form stable feed-forward loops which ensure prolongation of the signal, contributing to sustained activation. Members of the annexin protein family act as sensors for Ca2+, pH, and lipid second messengers, and regulate various signalling pathways. Recently, annexins were reported to participate in feedback loops, suppressing miRNA synthesis and attenuating stress-induced dysregulation of gene expression. They can directly or indirectly associate with RNAs, and are transferred between the cells in exosomes and shed microvesicles. The ability of annexins to recruit other proteins and miRNAs into exosomes implicates them in control of cell–cell interactions, affecting the adaptive responses and remodelling processes during disease. The studies summarized in this Review point to an emerging role of annexins in influencing the synthesis, localisation, and transfer of regulatory RNAs. View Full-Text
Keywords: annexin; miRNA; signalling; exosome; gene expression annexin; miRNA; signalling; exosome; gene expression

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Monastyrskaya, K. Functional Association between Regulatory RNAs and the Annexins. Int. J. Mol. Sci. 2018, 19, 591.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top