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Int. J. Mol. Sci. 2018, 19(2), 591; https://doi.org/10.3390/ijms19020591

Functional Association between Regulatory RNAs and the Annexins

Urology Research Laboratory, Department for BioMedical Research, University of Bern, 3008 Bern, Switzerland
Received: 6 January 2018 / Revised: 12 February 2018 / Accepted: 14 February 2018 / Published: 16 February 2018
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Abstract

Cells respond to pathophysiological states by activation of stress-induced signalling. Regulatory non-coding microRNAs (miRNAs) often form stable feed-forward loops which ensure prolongation of the signal, contributing to sustained activation. Members of the annexin protein family act as sensors for Ca2+, pH, and lipid second messengers, and regulate various signalling pathways. Recently, annexins were reported to participate in feedback loops, suppressing miRNA synthesis and attenuating stress-induced dysregulation of gene expression. They can directly or indirectly associate with RNAs, and are transferred between the cells in exosomes and shed microvesicles. The ability of annexins to recruit other proteins and miRNAs into exosomes implicates them in control of cell–cell interactions, affecting the adaptive responses and remodelling processes during disease. The studies summarized in this Review point to an emerging role of annexins in influencing the synthesis, localisation, and transfer of regulatory RNAs. View Full-Text
Keywords: annexin; miRNA; signalling; exosome; gene expression annexin; miRNA; signalling; exosome; gene expression
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Monastyrskaya, K. Functional Association between Regulatory RNAs and the Annexins. Int. J. Mol. Sci. 2018, 19, 591.

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