Next Article in Journal
Peripheral B-Cell Subset Distribution in Primary Antiphospholipid Syndrome
Next Article in Special Issue
The Balance of Th17 versus Treg Cells in Autoimmunity
Previous Article in Journal
Integrins Were Involved in Soybean Agglutinin Induced Cell Apoptosis in IPEC-J2
Previous Article in Special Issue
Lipopolysaccharide-Induced Acute Kidney Injury Is Dependent on an IL-18 Receptor Signaling Pathway
 
 
Review

New Insights into the Immune Molecular Regulation of the Pathogenesis of Acute Respiratory Distress Syndrome

1
Division of Chest Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
2
Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan
3
Department of Emergency Medicine, School of Medicine, Tzu Chi University, Hualien 970, Taiwan
4
Division of Thoracic Surgery, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan
5
School of Surgery, Tzu Chi University, Hualien 970, Taiwan
6
Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
7
Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, Show Chwan Memorial Hospital, Changhua 500, Taiwan
8
Department of Nursing, Meiho University, Pingtung 912, Taiwan
9
Research Assistant Center, Show Chwan Memorial Hospital, Changhua 500, Taiwan
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(2), 588; https://doi.org/10.3390/ijms19020588
Received: 22 January 2018 / Revised: 11 February 2018 / Accepted: 14 February 2018 / Published: 16 February 2018
(This article belongs to the Special Issue Signaling Pathway of Immune Cells and Immune Disorder)
Acute respiratory distress syndrome is an inflammatory disease characterized by dysfunction of pulmonary epithelial and capillary endothelial cells, infiltration of alveolar macrophages and neutrophils, cell apoptosis, necroptosis, NETosis, and fibrosis. Inflammatory responses have key effects on every phase of acute respiratory distress syndrome. The severe inflammatory cascades impaired the regulation of vascular endothelial barrier and vascular permeability. Therefore, understanding the relationship between the molecular regulation of immune cells and the pulmonary microenvironment is critical for disease management. This article reviews the current clinical and basic research on the pathogenesis of acute respiratory distress syndrome, including information on the microenvironment, vascular endothelial barrier and immune mechanisms, to offer a strong foundation for developing therapeutic interventions. View Full-Text
Keywords: acute respiratory distress syndrome; vascular permeability; NETosis; sepsis acute respiratory distress syndrome; vascular permeability; NETosis; sepsis
Show Figures

Figure 1

MDPI and ACS Style

Yang, C.-Y.; Chen, C.-S.; Yiang, G.-T.; Cheng, Y.-L.; Yong, S.-B.; Wu, M.-Y.; Li, C.-J. New Insights into the Immune Molecular Regulation of the Pathogenesis of Acute Respiratory Distress Syndrome. Int. J. Mol. Sci. 2018, 19, 588. https://doi.org/10.3390/ijms19020588

AMA Style

Yang C-Y, Chen C-S, Yiang G-T, Cheng Y-L, Yong S-B, Wu M-Y, Li C-J. New Insights into the Immune Molecular Regulation of the Pathogenesis of Acute Respiratory Distress Syndrome. International Journal of Molecular Sciences. 2018; 19(2):588. https://doi.org/10.3390/ijms19020588

Chicago/Turabian Style

Yang, Chin-Yao, Chien-Sheng Chen, Giou-Teng Yiang, Yeung-Leung Cheng, Su-Boon Yong, Meng-Yu Wu, and Chia-Jung Li. 2018. "New Insights into the Immune Molecular Regulation of the Pathogenesis of Acute Respiratory Distress Syndrome" International Journal of Molecular Sciences 19, no. 2: 588. https://doi.org/10.3390/ijms19020588

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop