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Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer

Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome, 00185 Rome, Italy
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Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(2), 570; https://doi.org/10.3390/ijms19020570
Received: 28 December 2017 / Revised: 13 February 2018 / Accepted: 13 February 2018 / Published: 14 February 2018
Long noncoding RNAs (lncRNAs) are important regulators of the epigenetic status of the human genome. Besides their participation to normal physiology, lncRNA expression and function have been already associated to many diseases, including cancer. By interacting with epigenetic regulators and by controlling chromatin topology, their misregulation may result in an aberrant regulation of gene expression that may contribute to tumorigenesis. Here, we review the functional role and mechanisms of action of lncRNAs implicated in the aberrant epigenetic regulation that has characterized cancer development and progression. View Full-Text
Keywords: lncRNA; epigenetics; chromatin; cancer lncRNA; epigenetics; chromatin; cancer
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Morlando, M.; Fatica, A. Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer. Int. J. Mol. Sci. 2018, 19, 570.

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