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Article

Preventive Effects of Resveratrol on Endocannabinoid System and Synaptic Protein Modifications in Rat Cerebral Cortex Challenged by Bilateral Common Carotid Artery Occlusion and Reperfusion

by
Gianfranca Carta
,
Laura Poddighe
,
Maria Pina Serra
,
Marianna Boi
,
Tiziana Melis
,
Sara Lisai
,
Elisabetta Murru
,
Laura Muredda
,
Maria Collu
,
Sebastiano Banni
and
Marina Quartu
*
Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(2), 426; https://doi.org/10.3390/ijms19020426
Submission received: 27 December 2017 / Revised: 18 January 2018 / Accepted: 19 January 2018 / Published: 31 January 2018
(This article belongs to the Special Issue The Beneficial Effects of Plant Oil on Human Health)
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Abstract

This study aims to evaluate the putative roles of a single acute dose of resveratrol (RVT) in preventing cerebral oxidative stress induced by bilateral common carotid artery occlusion, followed by reperfusion (BCCAO/R) and to investigate RVT’s ability to preserve the neuronal structural integrity. Frontal and temporal-occipital cortices were examined in two groups of adult Wistar rats, sham-operated and submitted to BCCAO/R. In both groups, 6 h before surgery, half the rats were gavage-fed with a single dose of RVT (40 mg/per rat in 300 µL of sunflower oil as the vehicle), while the second half received the vehicle alone. In the frontal cortex, RVT pre-treatment prevented the BCCAO/R-induced increase of lipoperoxides, augmented concentrations of palmitoylethanolamide and docosahexaenoic acid, increased relative levels of the cannabinoid receptors type 1 (CB1) and 2 (CB2), and peroxisome-proliferator-activated-receptor (PPAR)-α proteins. Increased expression of CB1/CB2 receptors mirrored that of synaptophysin and post-synaptic density-95 protein. No BCCAO/R-induced changes occurred in the temporal-occipital cortex. Collectively, our results demonstrate that, in the frontal cortex, RVT pre-treatment prevents the BCCAO/R-induced oxidative stress and modulates the endocannabinoid and PPAR-α systems. The increased expression of synaptic structural proteins further suggests the possible efficacy of RVT as a dietary supplement to preserve the nervous tissue metabolism and control the physiological response to the hypoperfusion/reperfusion challenge.
Keywords: bilateral common carotid artery occlusion; cerebral cortex; lipoperoxides; endocannabinoid system; PPAR-α; resveratrol; synaptic proteins bilateral common carotid artery occlusion; cerebral cortex; lipoperoxides; endocannabinoid system; PPAR-α; resveratrol; synaptic proteins
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MDPI and ACS Style

Carta, G.; Poddighe, L.; Serra, M.P.; Boi, M.; Melis, T.; Lisai, S.; Murru, E.; Muredda, L.; Collu, M.; Banni, S.; et al. Preventive Effects of Resveratrol on Endocannabinoid System and Synaptic Protein Modifications in Rat Cerebral Cortex Challenged by Bilateral Common Carotid Artery Occlusion and Reperfusion. Int. J. Mol. Sci. 2018, 19, 426. https://doi.org/10.3390/ijms19020426

AMA Style

Carta G, Poddighe L, Serra MP, Boi M, Melis T, Lisai S, Murru E, Muredda L, Collu M, Banni S, et al. Preventive Effects of Resveratrol on Endocannabinoid System and Synaptic Protein Modifications in Rat Cerebral Cortex Challenged by Bilateral Common Carotid Artery Occlusion and Reperfusion. International Journal of Molecular Sciences. 2018; 19(2):426. https://doi.org/10.3390/ijms19020426

Chicago/Turabian Style

Carta, Gianfranca, Laura Poddighe, Maria Pina Serra, Marianna Boi, Tiziana Melis, Sara Lisai, Elisabetta Murru, Laura Muredda, Maria Collu, Sebastiano Banni, and et al. 2018. "Preventive Effects of Resveratrol on Endocannabinoid System and Synaptic Protein Modifications in Rat Cerebral Cortex Challenged by Bilateral Common Carotid Artery Occlusion and Reperfusion" International Journal of Molecular Sciences 19, no. 2: 426. https://doi.org/10.3390/ijms19020426

APA Style

Carta, G., Poddighe, L., Serra, M. P., Boi, M., Melis, T., Lisai, S., Murru, E., Muredda, L., Collu, M., Banni, S., & Quartu, M. (2018). Preventive Effects of Resveratrol on Endocannabinoid System and Synaptic Protein Modifications in Rat Cerebral Cortex Challenged by Bilateral Common Carotid Artery Occlusion and Reperfusion. International Journal of Molecular Sciences, 19(2), 426. https://doi.org/10.3390/ijms19020426

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