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Open AccessReview

The Epigenetic Regulation of HCC Metastasis

by Tae-Su Han 1,†, Hyun Seung Ban 1,†, Keun Hur 2,* and Hyun-Soo Cho 1,*
1
Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea
2
Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu 41944, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(12), 3978; https://doi.org/10.3390/ijms19123978
Received: 14 November 2018 / Revised: 5 December 2018 / Accepted: 7 December 2018 / Published: 10 December 2018
Epigenetic alterations, such as histone modification, DNA methylation, and miRNA-mediated processes, are critically associated with various mechanisms of proliferation and metastasis in several types of cancer. To overcome the side effects and limited effectiveness of drugs for cancer treatment, there is a continuous need for the identification of more effective drug targets and the execution of mechanism of action (MOA) studies. Recently, epigenetic modifiers have been recognized as important therapeutic targets for hepatocellular carcinoma (HCC) based on their reported abilities to suppress HCC metastasis and proliferation in both in vivo and in vitro studies. Therefore, here, we introduce epigenetic modifiers and alterations related to HCC metastasis and proliferation, and their molecular mechanisms in HCC metastasis. The existing data suggest that the study of epigenetic modifiers is important for the development of specific inhibitors and diagnostic targets for HCC treatment. View Full-Text
Keywords: epigenetics; miRNA; DNA methylation; histone methylation; HCC; metastasis epigenetics; miRNA; DNA methylation; histone methylation; HCC; metastasis
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Han, T.-S.; Ban, H.S.; Hur, K.; Cho, H.-S. The Epigenetic Regulation of HCC Metastasis. Int. J. Mol. Sci. 2018, 19, 3978.

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