Next Article in Journal
Matrix Metalloproteinase Response of Dendritic Cell, Gingival Epithelial Keratinocyte, and T-Cell Transwell Co-Cultures Treated with Porphyromonas gingivalis Hemagglutinin-B
Next Article in Special Issue
Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis
Previous Article in Journal
LeNRT1.1 Improves Nitrate Uptake in Grafted Tomato Plants under High Nitrogen Demand
Previous Article in Special Issue
Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(12), 3922; https://doi.org/10.3390/ijms19123922

Drosophila as a Model to Study Brain Innate Immunity in Health and Disease

Department of Biological Sciences, 300 Hackberry lane, Tuscaloosa, AL 35487, USA
*
Author to whom correspondence should be addressed.
Received: 19 November 2018 / Revised: 5 December 2018 / Accepted: 5 December 2018 / Published: 7 December 2018
(This article belongs to the Special Issue Drosophila Model and Human Disease)
Full-Text   |   PDF [694 KB, uploaded 7 December 2018]   |  

Abstract

Innate immunity is the first line of defense against invading pathogens and plays an essential role in defending the brain against infection, injury, and disease. It is currently well recognized that central nervous system (CNS) infections can result in long-lasting neurological sequelae and that innate immune and inflammatory reactions are highly implicated in the pathogenesis of neurodegeneration. Due to the conservation of the mechanisms that govern neural development and innate immune activation from flies to mammals, the lack of a classical adaptive immune system and the availability of numerous genetic and genomic tools, the fruit fly Drosophila melanogaster presents opportunities to investigate the cellular and molecular mechanisms associated with immune function in brain tissue and how they relate to infection, injury and neurodegenerative diseases. Here, we present an overview of currently identified innate immune mechanisms specific to the adult Drosophila brain. View Full-Text
Keywords: Drosophila; innate immunity; inflammaging; neurodegeneration; brain infection; phagocytosis; autophagy Drosophila; innate immunity; inflammaging; neurodegeneration; brain infection; phagocytosis; autophagy
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Lye, S.H.; Chtarbanova, S. Drosophila as a Model to Study Brain Innate Immunity in Health and Disease. Int. J. Mol. Sci. 2018, 19, 3922.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top