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Volume 19
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Review

Calcium Signaling in Cholangiocytes: Methods, Mechanisms, and Effects

by
Michele Angela Rodrigues
1,
Dawidson Assis Gomes
1,2 and
Michael Harris Nathanson
1,*
1
Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8019, USA
2
Department of Biochemistry and Immunology, Federal University of Minas Gerais. Av. Antônio Carlos, 6627, Belo Horizonte—MG 31270-901, Brazil
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(12), 3913; https://doi.org/10.3390/ijms19123913
Submission received: 22 October 2018 / Revised: 13 November 2018 / Accepted: 20 November 2018 / Published: 6 December 2018
(This article belongs to the Special Issue Molecular and Cellular Interactions in Biliary Tree Development, Diseases and Cancer)
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Abstract

Calcium (Ca2+) is a versatile second messenger that regulates a number of cellular processes in virtually every type of cell. The inositol 1,4,5-trisphosphate receptor (ITPR) is the only intracellular Ca2+ release channel in cholangiocytes, and is therefore responsible for Ca2+-mediated processes in these cells. This review will discuss the machinery responsible for Ca2+ signals in these cells, as well as experimental models used to investigate cholangiocyte Ca2+ signaling. We will also discuss the role of Ca2+ in the normal and abnormal regulation of secretion and apoptosis in cholangiocytes, two of the best characterized processes mediated by Ca2+ in this cell type.
Keywords: Ca2+; inositol 1,4,5-trisphosphate (InsP3); inositol 1,4,5-trisphosphate receptors (ITPRs); cholangiocytes; biliary tree; secretion Ca2+; inositol 1,4,5-trisphosphate (InsP3); inositol 1,4,5-trisphosphate receptors (ITPRs); cholangiocytes; biliary tree; secretion

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MDPI and ACS Style

Rodrigues, M.A.; Gomes, D.A.; Nathanson, M.H. Calcium Signaling in Cholangiocytes: Methods, Mechanisms, and Effects. Int. J. Mol. Sci. 2018, 19, 3913. https://doi.org/10.3390/ijms19123913

AMA Style

Rodrigues MA, Gomes DA, Nathanson MH. Calcium Signaling in Cholangiocytes: Methods, Mechanisms, and Effects. International Journal of Molecular Sciences. 2018; 19(12):3913. https://doi.org/10.3390/ijms19123913

Chicago/Turabian Style

Rodrigues, Michele Angela, Dawidson Assis Gomes, and Michael Harris Nathanson. 2018. "Calcium Signaling in Cholangiocytes: Methods, Mechanisms, and Effects" International Journal of Molecular Sciences 19, no. 12: 3913. https://doi.org/10.3390/ijms19123913

APA Style

Rodrigues, M. A., Gomes, D. A., & Nathanson, M. H. (2018). Calcium Signaling in Cholangiocytes: Methods, Mechanisms, and Effects. International Journal of Molecular Sciences, 19(12), 3913. https://doi.org/10.3390/ijms19123913

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