Next Article in Journal
Cholesterol Increases Lipid Binding Rate and Changes Binding Behavior of Bacillus thuringiensis Cytolytic Protein
Next Article in Special Issue
The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers
Previous Article in Journal
Unambiguous Ex Situ and in Cell 2D 13C Solid-State NMR Characterization of Starch and Its Constituents
Previous Article in Special Issue
Blood‒Brain Barrier Pathology and CNS Outcomes in Streptococcus pneumoniae Meningitis
Review

Blood–Brain Barrier, Lymphatic Clearance, and Recovery: Ariadne’s Thread in Labyrinths of Hypotheses

1
Department of Human and Animal Physiology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia
2
Department of Optics and Biophotonics, Saratov State University, 83 Astrakhanskaya str., 410012 Saratov, Russia
3
Physics Department, Humboldt University, Newtonstrasse 15, 12489 Berlin, Germany
4
Potsdam Institute for Climate Impact Research, Telegrafenberg A31, 14473 Potsdam, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(12), 3818; https://doi.org/10.3390/ijms19123818
Received: 31 October 2018 / Revised: 21 November 2018 / Accepted: 23 November 2018 / Published: 30 November 2018
(This article belongs to the Special Issue Blood-Brain Barrier in CNS Injury and Repair, Volume 2)
The peripheral lymphatic system plays a crucial role in the recovery mechanisms after many pathological changes, such as infection, trauma, vascular, or metabolic diseases. The lymphatic clearance of different tissues from waste products, viruses, bacteria, and toxic proteins significantly contributes to the correspondent recovery processes. However, understanding of the cerebral lymphatic functions is a challenging problem. The exploration of mechanisms of lymphatic communication with brain fluids as well as the role of the lymphatic system in brain drainage, clearance, and recovery is still in its infancy. Here we review novel concepts on the anatomy and physiology of the lymphatics in the brain, which warrant a substantial revision of our knowledge about the role of lymphatics in the rehabilitation of the brain functions after neural pathologies. We discuss a new vision on the connective bridge between the opening of a blood–brain barrier and activation of the meningeal lymphatic clearance. The ability to stimulate the lymph flow in the brain, is likely to play an important role in developing future innovative strategies in neurorehabilitation therapy.
View Full-Text
Keywords: peripheral and meningeal lymphatics; blood-brain barrier; neurorehabilitation peripheral and meningeal lymphatics; blood-brain barrier; neurorehabilitation
Show Figures

Graphical abstract

MDPI and ACS Style

Semyachkina-Glushkovskaya, O.; Postnov, D.; Kurths, J. Blood–Brain Barrier, Lymphatic Clearance, and Recovery: Ariadne’s Thread in Labyrinths of Hypotheses. Int. J. Mol. Sci. 2018, 19, 3818. https://doi.org/10.3390/ijms19123818

AMA Style

Semyachkina-Glushkovskaya O, Postnov D, Kurths J. Blood–Brain Barrier, Lymphatic Clearance, and Recovery: Ariadne’s Thread in Labyrinths of Hypotheses. International Journal of Molecular Sciences. 2018; 19(12):3818. https://doi.org/10.3390/ijms19123818

Chicago/Turabian Style

Semyachkina-Glushkovskaya, Oxana, Dmitry Postnov, and Jürgen Kurths. 2018. "Blood–Brain Barrier, Lymphatic Clearance, and Recovery: Ariadne’s Thread in Labyrinths of Hypotheses" International Journal of Molecular Sciences 19, no. 12: 3818. https://doi.org/10.3390/ijms19123818

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop