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The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers

Max Delbrück Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany
Institute of Plant Biology and Biotechnology (IBBP), Westfälische Wilhelms-Universität Münster, Schlossgarten 3, 48149 Münster, Germany
Deparment of Anaesthesia and Critical Care, University of Würzburg, Oberdürrbacher Straße 6, 97080 Würzburg, Germany
Biomedical Technology Center of the Medical Faculty, Westfälische Wilhelms-Universität Münster Mendelstraße 17, 48149 Münster, Germany
Department of Dermatology and Venerology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(1), 122;
Received: 31 October 2018 / Revised: 20 December 2018 / Accepted: 21 December 2018 / Published: 30 December 2018
(This article belongs to the Special Issue Blood-Brain Barrier in CNS Injury and Repair, Volume 2)
Microvascular endothelial cells are an essential part of many biological barriers, such as the blood–brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions. View Full-Text
Keywords: tight junctions; capsaicin; endothelial cells tight junctions; capsaicin; endothelial cells
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MDPI and ACS Style

Kaiser, M.; Burek, M.; Britz, S.; Lankamp, F.; Ketelhut, S.; Kemper, B.; Förster, C.; Gorzelanny, C.; Goycoolea, F.M. The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers. Int. J. Mol. Sci. 2019, 20, 122.

AMA Style

Kaiser M, Burek M, Britz S, Lankamp F, Ketelhut S, Kemper B, Förster C, Gorzelanny C, Goycoolea FM. The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers. International Journal of Molecular Sciences. 2019; 20(1):122.

Chicago/Turabian Style

Kaiser, Mathias, Malgorzata Burek, Stefan Britz, Frauke Lankamp, Steffi Ketelhut, Björn Kemper, Carola Förster, Christian Gorzelanny, and Francisco M. Goycoolea 2019. "The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers" International Journal of Molecular Sciences 20, no. 1: 122.

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