Next Article in Journal
Effect of Acute Stress on the Expression of BDNF, trkB, and PSA-NCAM in the Hippocampus of the Roman Rats: A Genetic Model of Vulnerability/Resistance to Stress-Induced Depression
Previous Article in Journal
Wnt/β-Catenin Signaling Pathway Governs a Full Program for Dopaminergic Neuron Survival, Neurorescue and Regeneration in the MPTP Mouse Model of Parkinson’s Disease
Previous Article in Special Issue
Fingerprinting Acute Digestive Diseases by Untargeted NMR Based Metabolomics
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2018, 19(12), 3744; https://doi.org/10.3390/ijms19123744

In-and-Out Molecular Changes Linked to the Type 2 Diabetes Remission after Bariatric Surgery: An Influence of Gut Microbes on Mitochondria Metabolism

1
Clinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, Poland
2
1st Clinical Department of General and Endocrine Surgery, Medical University of Bialystok, 15-276 Bialystok, Poland
3
Center for Metabolomics and Bioanalysis (CEMBIO), Universidad CEU-San Pablo, km 0, Urbanización Montepríncipe. M-501, Alcorcón, 28925 Madrid, Spain
4
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland
*
Author to whom correspondence should be addressed.
Received: 3 November 2018 / Accepted: 15 November 2018 / Published: 24 November 2018
(This article belongs to the Special Issue Metabonomics in Gastroenterology and Hepatology)
Full-Text   |   PDF [2140 KB, uploaded 24 November 2018]   |  

Abstract

Different kinds of gastrointestinal tract modulations known as “bariatric surgery” are actually the most effective treatment for obesity and associated co-morbidities, such as type 2 diabetes (T2DM). The potential causes of those effects have yet to be explained. In our study, we focused on molecular changes evoked by laparoscopic sleeve gastrectomy leading to T2DM remission. Two complementary metabolomics techniques, namely, liquid chromatography coupled with mass spectrometry (LC-MS) and gas chromatography mass spectrometry (GC-MS), were used to study those effects in a group of 20 obese patients with T2DM selected from a cohort of 372 obese individuals who underwent bariatric surgery and did not receive anti-diabetic treatment afterward. Modified levels of carnitines, lipids, amino acids (including BCAA) and α- and β-hydroxybutyric acids were detected. Presented alterations suggest a major role of mitochondria activity in T2DM remission process. Moreover, some of the observed metabolites suggest that changes in gut microbiota composition may also correlate with the tempo of diabetes recovery. Additional analyses confirmed a relationship between biochemical and clinical parameters and the aforementioned metabolites, thereby, highlighting a role of mitochondria and microbes. Our data suggests that there is a previously undescribed relationship between mitochondria and gut microbiota, which changes after the bariatric surgery. More investigations are needed to confirm and explore the observed findings. View Full-Text
Keywords: bariatric surgery; metabolomics; diabetes remission; laparoscopic sleeve gastrectomy; LC-MS; GC-MS bariatric surgery; metabolomics; diabetes remission; laparoscopic sleeve gastrectomy; LC-MS; GC-MS
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Samczuk, P.; Hady, H.R.; Adamska-Patruno, E.; Citko, A.; Dadan, J.; Barbas, C.; Kretowski, A.; Ciborowski, M. In-and-Out Molecular Changes Linked to the Type 2 Diabetes Remission after Bariatric Surgery: An Influence of Gut Microbes on Mitochondria Metabolism. Int. J. Mol. Sci. 2018, 19, 3744.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top