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The Impact of miRNA in Colorectal Cancer Progression and Its Liver Metastases

by Ovidiu Balacescu 1,2,*,†, Daniel Sur 2,3,†, Calin Cainap 2,3,†, Simona Visan 1,†, Daniel Cruceriu 1,4,†, Roberta Manzat-Saplacan 5,6,†, Mihai-Stefan Muresan 7,8,†, Loredana Balacescu 1,2,†, Cosmin Lisencu 8,9,† and Alexandru Irimie 8,9,†
1
Department of Functional Genomics, Proteomics and Experimental Pathology, The Oncology Institute “Prof. Dr. Ion Chiricuta”, Cluj-Napoca 400015, Romania
2
11th Department of Medical Oncology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca 400015, Romania
3
Department of Medical Oncology, The Oncology Institute “Prof. Dr. Ion Chiricuta”, Cluj-Napoca 400015, Romania
4
Department of Molecular Biology and Biotechnology, “Babes-Bolyai” University, Cluj-Napoca 400006, Romania
5
5th Department of Internal Medicine, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca 400006, Romania
6
Department of Gastroenterology, Wilhelmina Hospital Assen, Europaweg-Zuid 1, 9401 RK Assen, The Netherlands
7
Department of Surgery, Municipal Hospital, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca 400139, Romania
8
11th Department of Oncological Surgery and Gynecological Oncology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca 400015, Romania
9
Department of Surgery, The Oncology Institute “Prof. Dr. Ion Chiricuta”, Cluj-Napoca 400015, Romania
*
Author to whom correspondence should be addressed.
All authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(12), 3711; https://doi.org/10.3390/ijms19123711
Received: 27 October 2018 / Revised: 19 November 2018 / Accepted: 20 November 2018 / Published: 22 November 2018
(This article belongs to the Special Issue Basic and Translational Research in Colorectal Cancer)
Colorectal cancer (CRC) is one of the most commonly diagnosed malignancies with a high incidence and mortality rate. An essential challenge in colorectal cancer management is to identify new prognostic factors that could better estimate the evolution and treatment responses of this disease. Considering their role in cancer development, progression and metastasis, miRNAs have become an important class of molecules suitable for cancer biomarkers discovery. We performed a systematic search of studies investigating the role of miRNAs in colorectal progression and liver metastasis published until October 2018. In this review, we present up-to-date information regarding the specific microRNAs involved in CRC development, considering their roles in alteration of Wnt/βcatenin, EGFR, TGFβ and TP53 signaling pathways. We also emphasize the role of miRNAs in controlling the epithelial–mesenchymal transition of CRC cells, a process responsible for liver metastasis in a circulating tumor cell-dependent manner. Furthermore, we discuss the role of miRNAs transported by CRC-derived exosomes in mediating liver metastases, by preparing the secondary pre-metastatic niche and in inducing liver carcinogenesis in a Dicer-dependent manner. View Full-Text
Keywords: miRNAs; colorectal cancer; exosomes; liver; metastases miRNAs; colorectal cancer; exosomes; liver; metastases
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Balacescu, O.; Sur, D.; Cainap, C.; Visan, S.; Cruceriu, D.; Manzat-Saplacan, R.; Muresan, M.-S.; Balacescu, L.; Lisencu, C.; Irimie, A. The Impact of miRNA in Colorectal Cancer Progression and Its Liver Metastases. Int. J. Mol. Sci. 2018, 19, 3711.

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